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Updated: May 11, 2026

Granulocyte-dependent Autoantibody-induced Skin Blistering
Published on: October 12, 2012
Generalized granuloma annulare presenting with lesions resembling eruptive xanthoma
Rujee Phuardchantuk1, Penvadee Pattanaprichakul, Panitta Sitthinamsuwan
1Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand. penvadee.pat@mahidol.ac.th
Abstract:
Generalized granuloma annulare (GGA) and eruptive xanthoma are dermatological diseases that occasionally share some clinical and histological similarities. Associated underlying medical conditions and clinical course are essential guides to the proper diagnosis. The authors reported a case ofdisseminatedyellowish-redpapules in a 24-year-old female with high levels of serum fasting blood sugar triglycerides, and cholesterol. The provisional diagnosis was eruptive xanthoma but histopathology and immunoperoxidase study revealed granuloma annulare. The remission of the skin lesions soon after control of dyslipidemia and diabetes mellitus is not typical for the usual GGA, which has a chronic relapsing course and a poor response to treatment. Further studies are required to differentiate these two entities when they come into the clinicopathological mimicry.
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