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Related Concept Videos

Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
Tissue Transplantation01:24

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
Kidney Transplant III: Nursing Management01:16

Kidney Transplant III: Nursing Management

Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...

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A randomized controlled trial of presatovir for respiratory syncytial virus after lung transplant.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation·2023
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Lung and liver transplantation in patients with alpha-1 antitrypsin deficiency.

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Ribavirin and cellular ribavirin-triphosphate concentrations in blood and bronchoalveolar lavage fluid in two lung transplant patients with respiratory syncytial virus.

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Respiratory viral infections post-lung transplantation.

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Update on Bronchiolitis Obliterans Syndrome in Lung Transplantation.

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Anti-LFA-1 induces CD8 T-cell dependent allograft tolerance and augments suppressor phenotype CD8 cells.

Cellular immunology·2018
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Clinical Relevance of Donor-Specific IgM Antibodies in HLA Incompatible Renal Transplantation: A Retrospective Single-Center Study.

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Influenza Immunization and the Generation of Anti-HLA and Anti-MICA Antibodies in Patients with Renal Failure and in Kidney Transplant Recipients.

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Related Experiment Video

Updated: May 11, 2026

Left Lung Orthotopic Transplantation in a Juvenile Porcine Model for ESLP
06:55

Left Lung Orthotopic Transplantation in a Juvenile Porcine Model for ESLP

Published on: February 14, 2022

Updates in lung transplantation.

Martin R Zamora1

  • 1University of Colorado Health Sciences Center, Aurora, Colorado, USA. marty.zamora@ucdenver.edu

Clinical Transplants
|June 1, 2013
PubMed
Summary
This summary is machine-generated.

Lung transplant (LTX) advances include expanded donor pools and improved survival for critically ill patients. A new classification system, chronic lung allograft dysfunction (CLAD), addresses long-term survival limitations.

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Related Experiment Videos

Last Updated: May 11, 2026

Left Lung Orthotopic Transplantation in a Juvenile Porcine Model for ESLP
06:55

Left Lung Orthotopic Transplantation in a Juvenile Porcine Model for ESLP

Published on: February 14, 2022

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Published on: October 11, 2024

Murine Intrapulmonary Tracheal Transplantation: A Model for Investigating Obliterative Airway Disease After Lung Transplantation
06:15

Murine Intrapulmonary Tracheal Transplantation: A Model for Investigating Obliterative Airway Disease After Lung Transplantation

Published on: November 10, 2023

Area of Science:

  • Cardiothoracic Surgery
  • Transplantation Immunology
  • Pulmonary Medicine

Background:

  • Lung transplantation (LTX) has seen significant progress, with over 3500 cases reported in 2010.
  • Extracorporeal life support and ex-vivo lung perfusion have expanded eligibility and donor options.
  • Despite advances, chronic rejection, such as bronchiolitis obliterans syndrome (BOS), remains a challenge.

Purpose of the Study:

  • To review key advances in lung transplantation over the past year.
  • To highlight progress in managing high-risk recipients and donors.
  • To introduce the new classification of chronic lung allograft dysfunction (CLAD).

Main Methods:

  • Review of recent literature and registry data.
  • Analysis of emerging evidence in histopathology, radiology, and physiology.
  • Evaluation of recent clinical trials on immunosuppressive therapies.

Main Results:

  • Increased LTX activity with higher-risk candidates and donors has yielded acceptable survival rates.
  • Ex-vivo lung perfusion has broadened the donor pool.
  • Recognition of CLAD as a broader category of chronic lung failure beyond BOS.

Conclusions:

  • Advances in LTX have improved outcomes for critically ill patients.
  • Understanding of CLAD mechanisms (alloimmune, autoimmune, nonimmune) is evolving.
  • New therapies show promise for managing CLAD and improving long-term lung allograft survival.