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Published on: August 12, 2017

Changes in IgG subclasses of donor specific anti-HLA antibodies following bortezomib-based therapy for antibody

Dinesh Kannabhiran1, Matthew J Everly, Jennifer K Walker-McDermott

  • 1Department of Transplantation Medicine, Weill Cornell Medical College/New York-Presbyterian Hospital, New York, New York, USA.

Clinical Transplants
|June 1, 2013
PubMed

The predominant anti-HLA IgG subclass during antibody mediated rejection episodes is IgG1. Class I DSA IgG subclasses respond to single cycle of bortezomib-based therapy more frequently as compared to Class II DSA IgG subclasses. High titer Class II DSA IgG subclasses are less likely to respond to single cycle bortezomib-based therapy. Future studies are needed to determine if the response to bortezomib-based therapy is dependent on the type of DSA and/or the strength of the DSA at the time of antibody mediated rejection episode.

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