Related Experiment Video
Updated: May 11, 2026
11:56
Antimicrobial Peptides Produced by Selective Pressure Incorporation of Non-canonical Amino Acids
Published on: May 4, 2018
ACE inhibitory peptides derived from aquatic protein
Lin Lin1, Shun Lv, Xiaorong Zhang
1School of Biotechnology and Food Engineering, Hefei University of Technology, 193 Tunxi Road, Hefei 230009, People's Republic of China. linlinhfut@yahoo.com.cn
Current Protein & Peptide Science
|June 1, 2013
Summary
Bioactive peptides from aquatic protein show promise for lowering blood pressure by inhibiting angiotensin-converting enzyme (ACE). This review details their sources, mechanisms, and antihypertensive effects.
Area of Science:
- Biochemistry
- Pharmacology
- Food Science
Background:
- Bioactive peptides derived from aquatic proteins are gaining attention for their health benefits.
- Angiotensin-converting enzyme (ACE) inhibitory peptides are particularly significant for cardiovascular health.
- Aquatic protein sources offer a rich reservoir for these valuable peptides.
Purpose of the Study:
- To provide a comprehensive overview of ACE inhibitory peptides from aquatic proteins.
- To explore the sources, structure-activity relationships, and mechanisms of action of these peptides.
- To discuss the antihypertensive effects of marine-derived ACE inhibitory peptides.
Main Methods:
- Literature review of scientific databases.
- Analysis of studies on peptide identification and characterization.
- Synthesis of information on ACE inhibition and antihypertensive properties.
Main Results:
- Numerous aquatic protein sources yield peptides with significant ACE inhibitory activity.
- Structure-activity relationship studies reveal key features for potent ACE inhibition.
- ACE inhibitory peptides demonstrate both short-term and long-term antihypertensive effects in various models.
Conclusions:
- Aquatic protein-derived ACE inhibitory peptides represent a promising natural source for managing hypertension.
- Further research into their bioavailability and efficacy is warranted for therapeutic applications.
- These peptides hold potential for development into functional foods and pharmaceutical agents.
More Related Videos
Related Concept Videos
01:23Antimicrobial Proteins
Antimicrobial proteins are important components of the immune system. They aid the body in combating pathogens by either killing them directly or hindering their replication processes. Four main types of antimicrobial substances are interferons, the complement system, iron-binding proteins, and antimicrobial proteins.
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
01:18Indirect-Acting Cholinergic Agonists: Mechanism of Action
Indirect-acting cholinergic agonists work by interacting with an enzyme called acetylcholinesterase (AChE) in the synaptic cleft. They can be reversible or irreversible inhibitors and have different effects on the enzyme.
Reversible inhibitors like edrophonium bind to a specific part of the enzyme called the anionic catalytic site. They form noncovalent bonds, which means they are not strongly attached to the enzyme. This creates a temporary and less stable enzyme–inhibitor complex, leading to...
Reversible inhibitors like edrophonium bind to a specific part of the enzyme called the anionic catalytic site. They form noncovalent bonds, which means they are not strongly attached to the enzyme. This creates a temporary and less stable enzyme–inhibitor complex, leading to...
01:29Indirect-Acting Cholinergic Agonists: Chemistry and Structure-Activity Relationship
Indirect-acting cholinergic agonists are agents that interact with the acetylcholinesterase enzyme in the synaptic cleft, preventing the breakdown of acetylcholine into choline and acetate. Consequently, the concentration of acetylcholine in the synaptic cleft increases. These agonists can be classified into reversible and irreversible inhibitors based on their duration of action.
Reversible inhibitors display short to medium durations of action. Short-acting agents include simple alcohols with...
Reversible inhibitors display short to medium durations of action. Short-acting agents include simple alcohols with...
03:42Amino acids
Amino acids are the monomers that comprise proteins. Each amino acid has the same fundamental structure, which consists of a central carbon atom, or the alpha (α) carbon, bonded to an amino group (NH2), a carboxyl group (COOH), and to a hydrogen atom. Every amino acid also has another atom or group of atoms bonded to the central atom known as the R group. There are 20 common amino acids present in proteins, each with a different R group. Variation in the amino acid sequence is responsible for...
01:30Inhibitors of Viral Protein Synthesis
Protein synthesis is indispensable for viral replication, as viruses lack the cellular machinery required for this process and must hijack the host's translational apparatus. In response, host cells deploy a critical innate immune defense involving interferons, specialized cytokines that play a central role in inhibiting viral propagation.Upon viral detection, infected cells release interferons that bind to receptors on adjacent uninfected cells, activating the JAK-STAT signaling pathway and...
01:25Aquaporins
Aquaporins or AQPs are a family of integral membrane proteins whose primary function is to transport water, while some called aquaglyceroporins also transport glycerol. In addition, aquaporins have also been suspected to be involved in transporting volatile substances, such as carbon dioxide and ammonia, across membranes. Such AQPs that act as gas channels are often highly expressed in cells involved in the gaseous exchange, such as red blood cells, epithelial cells, and pulmonary capillaries.