Modelling airway smooth muscle passive length adaptation via thick filament length distributions

We present a new model of airway smooth muscle (ASM), which surrounds and constricts every airway in the lung and thus plays a central role in the airway constriction associated with asthma. This new model of ASM is based on an extension of sliding filament/crossbridge theory, which explicitly incorporates the length distribution of thick sliding filaments to account for a phenomenon known as dynamic passive length adaptation; the model exhibits good agreement with experimental data for ASM force-length behaviour across multiple scales. Principally these are (nonlinear) force-length loops at short timescales (seconds), parabolic force-length curves at medium timescales (minutes) and length adaptation at longer timescales. This represents a significant improvement on the widely-used crossbridge models which work so well in or near the isometric regime, and may have significant implications for studies which rely on crossbridge or other dynamic airway smooth muscle models, and thus both airway and lung dynamics.