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Functional connectivity abnormalities during contextual processing in schizophrenia and in Parkinson's disease
Noa Fogelson1, Ling Li, Yuan Li
1Department of Psychology, University of A Coruña, La Coruña, Spain. nfogelson@udc.es
Brain and Cognition
|June 1, 2013
Summary
Schizophrenia (SC) and Parkinson
Area of Science:
- Neuroscience
- Cognitive Neuroscience
- Computational Psychiatry
Background:
- Schizophrenia (SC) and Parkinson's disease (PD) are associated with contextual processing deficits.
- Functional disconnection is hypothesized to underlie these deficits.
Purpose of the Study:
- To investigate functional connectivity during local contextual processing in SC and PD patients.
- To determine if task-specific network abnormalities correlate with processing deficits.
Main Methods:
- Event-related electroencephalography (EEG) signals were analyzed.
- Synchronization likelihood and graph theoretical analysis (path length, cluster coefficients) were employed.
- A local contextual processing paradigm with predictive and random stimuli was used.
Main Results:
- SC patients showed decreased path length (beta band) and weaker frontal-temporal-parietal connections.
- PD patients exhibited longer path length (theta band) and higher cluster coefficients (theta, alpha bands).
- Detection of predicted targets in PD was linked to weaker frontal-parietal connections.
Conclusions:
- Task-specific functional connectivity abnormalities exist in SC and PD during local contextual processing.
- These abnormalities are primarily within frontal networks.
- Findings support the role of functional disconnection in contextual processing deficits in these patient groups.
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