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Updated: May 11, 2026

Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment
Published on: April 22, 2019
Cyclin B1 overexpression in conventional oral squamous cell carcinoma and verrucous carcinoma- A correlation with
Gururaj B Patil1, Kaveri S Hallikeri, Aswini Y Balappanavar
1Department of Oral and Maxillofacial Pathology, Jodhpur national University, Jodhpur dental college and Hospital, Jodhpur, Rajasthan, India . drgururajpatil@gmail.com
Background:
Nuclear localization of cyclin B1 is an indicator for cells undergoing mitotic division, and the overexpression has shown promising results as a good prognostic predictor for patients of squamous cell carcinoma (SCC). Cyclin B1 overexpression among histological grades of conventional oral squamous cell carcinoma (COSCC), as well as comparison with verrucous carcinoma (VC) has been less investigated.
Study Design:
Immunohistochemical expression of cyclin B1 was compared with various clinicopathological features in 30 primary COSCC and 31 primary VC cases.
Result:
Cyclin B1 showed significant overexpression for some clinical features for both the variants of oral squamous cell carcinoma. In histopathological variants, statistical significance was observed among grades of COSCC, as well as COSCC and its grades with VC. The concomitant increase in cyclin B1 overexpression from VC to grades COSCC was observed.
Conclusion:
Our study findings draw attention to cyclin B1 overexpression is involved in early carcinogenesis, cell differentiation and tumor proliferation.
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