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Updated: May 11, 2026
Assessment of Audio-Tactile Sensory Substitution Training in Participants with Profound Deafness Using the Event-Related Potential Technique
Published on: September 7, 2022
Gap detection measured with electrically evoked auditory event-related potentials and speech-perception abilities in
Shuman He1, John H Grose, Holly F B Teagle
1Department Otolaryngology-Head and Neck Surgery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Insights
Electrically evoked auditory event-related potentials (eERPs) can be recorded in children with auditory neuropathy spectrum disorder (ANSD). Larger electrically evoked auditory change complex (EACC) thresholds for gap detection correlate with poorer speech perception in these children.
Area of Science:
- Auditory Neuroscience
- Neurophysiology
- Speech-Language Pathology
Background:
- Auditory neuropathy spectrum disorder (ANSD) presents challenges in auditory processing and speech perception.
- Electrically evoked auditory event-related potentials (eERPs) offer a method to assess auditory pathway function in individuals with hearing impairments.
Purpose of the Study:
- To determine the feasibility of recording eERPs, including the onset P1-N1-P2 complex and the electrically evoked auditory change complex (EACC), in children with ANSD.
- To investigate the relationship between eERP measures and speech-perception abilities in children with ANSD.
Main Methods:
- Fifteen children with ANSD using cochlear implants underwent direct electrical stimulation.
- eERPs were elicited using trains of current pulses with varying temporal gaps (5-100 msec).
- Speech perception was assessed using phonetically balanced kindergarten word lists.
Main Results:
- eERPs were successfully recorded from all participating children with ANSD.
- No significant differences in onset P1-N1-P2 complex reliability or latency were found between groups with different speech-perception levels.
- The EACC showed a robust correlation with speech-perception scores, with poorer performers exhibiting higher EACC thresholds for gap detection.
Conclusions:
- Recording eERPs via direct electrical stimulation is feasible in implanted children with ANSD.
- Temporal processing deficits, indicated by elevated EACC thresholds, may contribute to speech-perception difficulties in some children with ANSD.
- The EACC shows promise as a predictor of speech-perception ability in this population.
Objectives:
This study aimed (1) to investigate the feasibility of recording the electrically evoked auditory event-related potential (eERP), including the onset P1-N1-P2 complex and the electrically evoked auditory change complex (EACC) in response to temporal gaps, in children with auditory neuropathy spectrum disorder (ANSD); and (2) to evaluate the relationship between these measures and speech-perception abilities in these subjects.
Design:
Fifteen ANSD children who are Cochlear Nucleus device users participated in this study. For each subject, the speech-processor microphone was bypassed and the eERPs were elicited by direct stimulation of one mid-array electrode (electrode 12). The stimulus was a train of biphasic current pulses 800 msec in duration. Two basic stimulation conditions were used to elicit the eERP. In the no-gap condition, the entire pulse train was delivered uninterrupted to electrode 12, and the onset P1-N1-P2 complex was measured relative to the stimulus onset. In the gapped condition, the stimulus consisted of two pulse train bursts, each being 400 msec in duration, presented sequentially on the same electrode and separated by one of five gaps (i.e., 5, 10, 20, 50, and 100 msec). Open-set speech-perception ability of these subjects with ANSD was assessed using the phonetically balanced kindergarten (PBK) word lists presented at 60 dB SPL, using monitored live voice in a sound booth.
Results:
The eERPs were recorded from all subjects with ANSD who participated in this study. There were no significant differences in test-retest reliability, root mean square amplitude or P1 latency for the onset P1-N1-P2 complex between subjects with good (>70% correct on PBK words) and poorer speech-perception performance. In general, the EACC showed less mature morphological characteristics than the onset P1-N1-P2 response recorded from the same subject. There was a robust correlation between the PBK word scores and the EACC thresholds for gap detection. Subjects with poorer speech-perception performance showed larger EACC thresholds in this study.
Conclusions:
These results demonstrate the feasibility of recording eERPs from implanted children with ANSD, using direct electrical stimulation. Temporal-processing deficits, as demonstrated by large EACC thresholds for gap detection, might account in part for the poor speech-perception performances observed in a subgroup of implanted subjects with ANSD. This finding suggests that the EACC elicited by changes in temporal continuity (i.e., gap) holds promise as a predictor of speech-perception ability among implanted children with ANSD.
