Related Experiment Video
Updated: May 11, 2026
A Mouse Distraction Osteogenesis Model
Published on: November 14, 2018
A systematic review on the outcome of mandibular distraction osteogenesis in infants suffering Robin sequence
Emma C Paes1, Aebele B Mink van der Molen, Marvick S M Muradin
1Department of Plastic, Reconstructive and Hand Surgery, Wilhelmina Children's Hospital, PO Box 85500, 3508 GA, Utrecht, the Netherlands, emmapaes@gmail.com.
Insights
Internal mandibular distraction osteogenesis (MDO) is feasible for Robin sequence (RS) infants, minimizing side effects. Further studies are needed to compare internal and external MDO for optimal treatment strategies.
Area of Science:
- Craniofacial surgery
- Pediatric surgery
- Orthognathic surgery
Background:
- Mandibular distraction osteogenesis (MDO) is used for Robin sequence (RS) infants with airway obstruction.
- Comparative studies on MDO types for RS are lacking.
Purpose of the Study:
- To systematically review MDO types for RS infants.
- To provide a basis for treatment protocols and strategies.
Main Methods:
- Systematic review of Pubmed, EMBASE, and Cochrane Library databases (1966-2012).
- Analysis of 12 selected studies on MDO types, patient characteristics, outcomes, and complications.
Main Results:
- 12 studies were included: 4 external MDO, 5 internal MDO, 3 both.
- Internal MDO shows feasibility with fewer side effects but has more limited indications.
Conclusions:
- Internal MDO is a viable option for RS infants, reducing scarring and nerve damage.
- Further research and long-term outcome studies are necessary for distinct comparisons and guideline development.
Objectives:
Mandibular distraction osteogenesis (MDO) has been successfully applied in infants suffering Robin sequence (RS) with severe upper airway obstruction, but no comparative studies for the different types of MDO exist to date. The objective of the current study was to systematically review the published data considering this matter, providing a fundament for protocols and a more conscious treatment strategy for infants with RS in the near future.
Material And Methods:
For the period from January 1966 to January 2012, the Pubmed, EMBASE, and Cochrane Library databases were searched. Abstracts were screened based on predetermined selection criteria. Relevant full-text articles were retrieved. The articles were analyzed on the type of MDO used, preoperative workup, patient characteristics, postoperative outcome, and complications.
Results:
The search yielded 109 articles. After checking abstracts and full texts on predetermined inclusion and exclusion criteria, 12 studies (four describing external MDO, five internal MDO, and three both types) were extracted for further analyses.
Conclusion:
Internal MDO seems very feasible in infants suffering RS, minimizing side effects such as hypertrophic scarring, nerve damage, and extensive care needs, although the indications for usage are more limited compared to the external device. Corresponding protocols and long-term outcome studies are needed to make a better comparison and the use and indication of the different types of distraction even more distinct.
Clinical Relevance:
A base for a guideline to support the choice of a designated operative management for neonates with RS is provided, hereby obviating possible complications of the different types of MDO in the future.
