Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Alzheimer's Disease: Treatment

Alzheimer's Disease: Treatment

Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...

Amyloid Fibrils

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins. Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils.
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining, normally used to...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

[Hemodynamic effects of synchronous and asynchronous independent lung ventilation with different levels of positive end-expiratory pressure and tidal volumes on unilateral lung injury in dogs].

Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases·2010

Same author

[Study on the immuno-effects and influencing factors of Chinese hamster ovary (CHO) cell hepatitis B vaccine among adults, under different dosages].

Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi·2010

Same author

Assemblies of fluorine containing bent-shaped liquid crystal molecules studied by using scanning tunneling microscopy.

Journal of nanoscience and nanotechnology·2010

Same author

Carbon nanotubes induce secondary structure changes of bovine albumin in aqueous phase.

Journal of nanoscience and nanotechnology·2010

Same author

[Immunogenicity and protective efficacy of pertactin recombinants against Bordetella bronchiseptica challenge].

Wei sheng wu xue bao = Acta microbiologica Sinica·2010

Same author

[Analysis of the electrocardiographic findings in 288 patients with acute pulmonary thromboembolism].

Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases·2010

Search research articles

Related Experiment Video

Updated: May 11, 2026

A11-positive β-amyloid Oligomer Preparation and Assessment Using Dot Blotting Analysis

A11-positive β-amyloid Oligomer Preparation and Assessment Using Dot Blotting Analysis

Published on: May 22, 2018

Nanomaterials for reducing amyloid cytotoxicity.

Min Zhang¹, Xiaobo Mao, Yue Yu

¹National Center for Nanoscience and Technology, Beijing 100190, China.

Advanced Materials (Deerfield Beach, Fla.)

|June 1, 2013

Summary

This review covers nanomaterials for treating amyloid diseases, detailing their anti-amyloid functions and targeted drug delivery capabilities. Nanomaterials offer improved therapeutic strategies for amyloidosis.

Keywords:

aggregation amyloid cytotoxicity inhibitor nanomaterials

More Related Videos

Characterization of pH-Dependent Reversible Self-Assembly of Amyloid Beta 1-40-Coated Gold Colloids

Characterization of pH-Dependent Reversible Self-Assembly of Amyloid Beta 1-40-Coated Gold Colloids

Published on: March 21, 2025

Fabrication of Amyloid-β-Secreting Alginate Microbeads for Use in Modelling Alzheimer's Disease

Fabrication of Amyloid-β-Secreting Alginate Microbeads for Use in Modelling Alzheimer's Disease

Published on: July 6, 2019

Related Experiment Videos

Last Updated: May 11, 2026

A11-positive β-amyloid Oligomer Preparation and Assessment Using Dot Blotting Analysis

A11-positive β-amyloid Oligomer Preparation and Assessment Using Dot Blotting Analysis

Published on: May 22, 2018

Characterization of pH-Dependent Reversible Self-Assembly of Amyloid Beta 1-40-Coated Gold Colloids

Characterization of pH-Dependent Reversible Self-Assembly of Amyloid Beta 1-40-Coated Gold Colloids

Published on: March 21, 2025

Fabrication of Amyloid-β-Secreting Alginate Microbeads for Use in Modelling Alzheimer's Disease

Fabrication of Amyloid-β-Secreting Alginate Microbeads for Use in Modelling Alzheimer's Disease

Published on: July 6, 2019

Area of Science:

Nanomedicine
Biomaterials Science
Neurodegenerative Diseases

Background:

Amyloid diseases, such as Alzheimer's and Parkinson's, are characterized by the accumulation of misfolded amyloid proteins.
Current therapeutic strategies for amyloid diseases have limitations in efficacy and targeted delivery.
Nanomaterials present a promising avenue for novel therapeutic interventions due to their unique properties.

Purpose of the Study:

To review recent advancements in the therapeutic applications of various nanomaterials for amyloid diseases.
To discuss the anti-amyloid functions, functionalization strategies, and interaction mechanisms of nanomaterials with amyloid peptides.
To explore the potential of nanomaterials in enhancing drug delivery for improved amyloid disease therapeutics.

Main Methods:

Comprehensive literature review of studies on nanomaterials in amyloid disease therapy.
Analysis of different types of nanomaterials, including inorganic nanoparticles, polymeric nanoparticles, carbon nanomaterials, and biomolecular aggregates.
Discussion of functionalization strategies for targeted drug delivery and interaction mechanisms between nanomaterials and amyloid peptides.

Main Results:

Various nanomaterials exhibit significant anti-amyloid functions, inhibiting aggregation and promoting clearance.
Functionalization of nanoparticles enables targeted delivery of therapeutics to amyloidogenic sites.
Nanomaterials facilitate enhanced drug encapsulation, controlled release, and blood-brain barrier penetration for improved treatment.

Conclusions:

Nanomaterials offer versatile platforms for developing advanced therapeutics against amyloid diseases.
Strategic application of nanomaterials can overcome limitations of conventional treatments by improving drug delivery and targeting.
Further research into nanomaterial-amyloid interactions and optimized delivery systems is crucial for clinical translation.