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Related Experiment Video

Updated: May 11, 2026

Microfluidic Model of Necrotizing Enterocolitis Incorporating Human Neonatal Intestinal Enteroids and a Dysbiotic Microbiome

Microfluidic Model of Necrotizing Enterocolitis Incorporating Human Neonatal Intestinal Enteroids and a Dysbiotic Microbiome

Published on: July 28, 2023

Transfusion-related necrotizing enterocolitis: a conceptual framework.

Terri Marin¹, Ora L Strickland

¹Nell Hodgson Woodruff School of Nursing, Emory University, Atlanta, GA, USA. tmarin@emory.edu

Advances in Neonatal Care : Official Journal of the National Association of Neonatal Nurses

|June 1, 2013

Summary

This summary is machine-generated.

Transfusion-related necrotizing enterocolitis (TR-NEC) affects premature infants receiving blood transfusions. This review explores how transfusions, feeding, and immature guts interact to increase TR-NEC risk.

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Last Updated: May 11, 2026

Microfluidic Model of Necrotizing Enterocolitis Incorporating Human Neonatal Intestinal Enteroids and a Dysbiotic Microbiome

Microfluidic Model of Necrotizing Enterocolitis Incorporating Human Neonatal Intestinal Enteroids and a Dysbiotic Microbiome

Published on: July 28, 2023

A Neonatal BALB/c Mouse Model of Necrotizing Enterocolitis

A Neonatal BALB/c Mouse Model of Necrotizing Enterocolitis

Published on: November 30, 2021

Area of Science:

Neonatalogy
Pediatric Gastroenterology
Critical Care Medicine

Background:

Necrotizing enterocolitis (NEC) is a severe intestinal disease in premature infants.
Transfusion-related NEC (TR-NEC) affects 25-35% of very low-birth-weight infants receiving packed red blood cell transfusions.
Known risk factors for NEC include packed red blood cell transfusions, enteral feedings, and gastrointestinal immaturity.

Purpose of the Study:

To present a conceptual framework for understanding transfusion-related NEC (TR-NEC).
To review existing research on factors contributing to TR-NEC.
To discuss the application of this framework for future research and nursing care.

Main Methods:

Literature review of previous research on NEC, TR-NEC, and related variables.
Synthesis of theoretical perspectives on TR-NEC.
Development of a conceptual framework integrating contributing factors.

Main Results:

Packed red blood cell transfusions, enteral feedings, and gastrointestinal immaturity may interact to impair neonatal intestinal tissue oxygenation.
This interaction can lead to tissue ischemia and subsequent intestinal injury, contributing to TR-NEC development.
The proposed framework integrates these factors to explain TR-NEC pathogenesis.

Conclusions:

A conceptual framework is proposed to elucidate the multifactorial etiology of TR-NEC.
Understanding the interplay of transfusion, feeding, and gut immaturity is crucial for TR-NEC prevention and management.
The framework can guide future research and inform clinical nursing practices for at-risk infants.