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Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System
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Published on: December 11, 2016

Defining "innovativeness" in drug development: a systematic review.

A S Kesselheim1, B Wang, J Avorn

  • 1Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA. akesselheim@partners.org

Clinical Pharmacology and Therapeutics
|June 1, 2013
PubMed
Summary
This summary is machine-generated.

The definition of pharmaceutical innovation significantly impacts study conclusions. Counting new drugs approved shows mixed trends, while other measures like therapeutic value indicate a decline in drug development innovation.

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The Innovation Arena: A Method for Comparing Innovative Problem-Solving Across Groups
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The Innovation Arena: A Method for Comparing Innovative Problem-Solving Across Groups
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Published on: May 13, 2022

Area of Science:

  • Pharmaceutical Science
  • Health Economics
  • Biotechnology

Background:

  • Debate exists regarding the pace of pharmaceutical innovation.
  • Discrepancies in findings may stem from varied innovation assessment methods.

Purpose of the Study:

  • To systematically review and categorize methods for measuring innovation in drug development.
  • To analyze how different measurement approaches influence conclusions about innovation trends.

Main Methods:

  • Conducted a systematic literature review of 42 studies on drug development innovation.
  • Classified studies into four main categories: drug counts, therapeutic value, economic outcomes, and patents.
  • Analyzed the conclusions of studies based on their chosen innovation metrics.

Main Results:

  • Studies using drug counts reported mixed trends (43% favorable, 52% unfavorable).
  • Studies using alternative measures (therapeutic value, economic outcomes, patents) showed no favorable trends (0% favorable, 47% unfavorable, 47% inconclusive).
  • A statistically significant difference (P = 0.03) was observed between the two measurement approaches.

Conclusions:

  • The method used to define and measure pharmaceutical innovation critically influences the perceived trend.
  • Reliance on simple drug counts may overestimate innovation compared to assessments of therapeutic value or economic impact.