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Published on: June 28, 2021
Ranitidine-associated recurrent acute pancreatitis
R Herrmann1, R G Shaw, D J Fone
1Department of Gastroenterology, Royal Melbourne Hospital, Victoria, Australia.
Ranitidine, a common peptic ulcer treatment, was linked to acute pancreatitis in one patient. The condition resolved upon drug discontinuation and recurred with re-exposure, indicating a potential adverse reaction.
Area of Science:
- Gastroenterology
- Clinical Pharmacology
Background:
- Ranitidine is a widely prescribed H2 receptor antagonist for peptic ulcer disease.
- It is generally considered safe with rare serious adverse reactions.
Observation:
- A case report details a patient experiencing recurrent acute pancreatitis.
- The pancreatitis episodes were temporally associated with ranitidine use for duodenal ulcer disease.
Findings:
- Each episode of acute pancreatitis resolved after ranitidine withdrawal.
- Pancreatitis recurred upon re-administration of ranitidine.
- Alternative causes of pancreatitis, including biliary and pancreatic disease, were ruled out.
Implications:
- This case suggests a potential causal link between ranitidine and acute pancreatitis in susceptible individuals.
- Clinicians should consider ranitidine as a potential etiology in patients presenting with unexplained acute pancreatitis.
- Further investigation into drug-induced pancreatitis may be warranted.
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Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
Acute Pancreatitis II: Clinical Manifestations and Management
Acute Pancreatitis I: Introduction
Acute Pancreatitis II: Pathophysiology
Chronic Pancreatitis II: Pathophysiology