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Ranitidine-associated recurrent acute pancreatitis.

R Herrmann1, R G Shaw, D J Fone

  • 1Department of Gastroenterology, Royal Melbourne Hospital, Victoria, Australia.

Australian and New Zealand Journal of Medicine
|June 1, 1990
PubMed
Summary
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Ranitidine, a common peptic ulcer treatment, was linked to acute pancreatitis in one patient. The condition resolved upon drug discontinuation and recurred with re-exposure, indicating a potential adverse reaction.

Area of Science:

  • Gastroenterology
  • Clinical Pharmacology

Background:

  • Ranitidine is a widely prescribed H2 receptor antagonist for peptic ulcer disease.
  • It is generally considered safe with rare serious adverse reactions.

Observation:

  • A case report details a patient experiencing recurrent acute pancreatitis.
  • The pancreatitis episodes were temporally associated with ranitidine use for duodenal ulcer disease.

Findings:

  • Each episode of acute pancreatitis resolved after ranitidine withdrawal.
  • Pancreatitis recurred upon re-administration of ranitidine.
  • Alternative causes of pancreatitis, including biliary and pancreatic disease, were ruled out.

Implications:

  • This case suggests a potential causal link between ranitidine and acute pancreatitis in susceptible individuals.

Related Experiment Videos

  • Clinicians should consider ranitidine as a potential etiology in patients presenting with unexplained acute pancreatitis.
  • Further investigation into drug-induced pancreatitis may be warranted.