Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Kidney Transplant III: Nursing Management

Kidney Transplant III: Nursing Management

Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...

Kidney Transplant I: Introduction

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...

Kidney Transplant II: Surgical Procedure

Kidney Transplant II: Surgical Procedure

Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living donor...

Peripheral Artery Disease V: Postoperative Nursing Management

Peripheral Artery Disease V: Postoperative Nursing Management

During the postoperative period, it is crucial to focus on maintaining circulation, identifying and managing potential complications, and planning for discharge.Nursing AssessmentVital signs monitoring: Regularly monitor vital signs, including blood pressure, heart rate, respiratory rate, and temperature, to detect early signs of complications such as bleeding and infection.Circulation assessment: Monitor pulses, perform Doppler assessments, and check capillary refill, color, temperature, and...

Tissue Transplantation

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...

Exercise and Cardiovascular Response

Exercise and Cardiovascular Response

Exercise significantly impacts cardiovascular response, which is crucial for understanding patient health and designing effective treatment plans.
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Diagnostic yield of exome reanalysis over time: Contribution of reevaluation type, timing, and patient phenotype.

Genetics in medicine : official journal of the American College of Medical Genetics·2026

Same author

Exercise attenuates stress-related signaling as sensed by higher phosphorylation of small heat shock proteins in skeletal muscle from older individuals.

Journal of sport and health science·2025

Same author

Immunohistopathology of Cochleovestibular Schwannoma in Human Temporal Bone Specimens.

Biology·2025

Same author

Exploring the impact of waiting time on physical function and psychosocial measures in individuals with lower limb osteoarthritis awaiting orthopaedic consultation.

Journal of health psychology·2025

Same author

Exercise- and diet-induced glycogen depletion impairs performance during one-legged constant-load, high-intensity exercise in humans.

Frontiers in physiology·2025

Same author

Genetic Analysis of Recently Discovered Least Chub Populations in the Upper Snake River and Bonneville Drainages.

Ecology and evolution·2025

Search research articles

Related Experiment Video

Updated: May 11, 2026

Transplantation of Induced Pluripotent Stem Cell-derived Mesoangioblast-like Myogenic Progenitors in Mouse Models of Muscle Regeneration

Transplantation of Induced Pluripotent Stem Cell-derived Mesoangioblast-like Myogenic Progenitors in Mouse Models of Muscle Regeneration

Published on: January 20, 2014

Exercise limitation following transplantation.

Trevor J Williams¹, Michael J McKenna

¹Department of Allergy, Immunology, and Respiratory Medicine Alfred Hospital and Monash University, Melbourne, Australia. t.williams@alfred.org.au

Comprehensive Physiology

|June 1, 2013

Summary

Organ transplantation improves quality of life but peak exercise capacity (VO2peak) remains low post-surgery. Skeletal muscle dysfunction, exacerbated by immunosuppressants, is a key factor limiting recovery.

More Related Videos

Early Weight-Bearing Rehabilitation Protocol After Anterior Cruciate Ligament Reconstruction

Early Weight-Bearing Rehabilitation Protocol After Anterior Cruciate Ligament Reconstruction

Published on: March 1, 2024

Related Experiment Videos

Last Updated: May 11, 2026

Transplantation of Induced Pluripotent Stem Cell-derived Mesoangioblast-like Myogenic Progenitors in Mouse Models of Muscle Regeneration

Transplantation of Induced Pluripotent Stem Cell-derived Mesoangioblast-like Myogenic Progenitors in Mouse Models of Muscle Regeneration

Published on: January 20, 2014

Early Weight-Bearing Rehabilitation Protocol After Anterior Cruciate Ligament Reconstruction

Early Weight-Bearing Rehabilitation Protocol After Anterior Cruciate Ligament Reconstruction

Published on: March 1, 2024

Area of Science:

Transplantation Medicine
Exercise Physiology
Immunosuppression

Background:

Organ transplantation significantly enhances quality of life for patients with chronic organ failure.
Despite improved organ function, post-transplant exercise performance is often limited.

Purpose of the Study:

To evaluate peak exercise performance (VO2peak) after common solid-organ transplants.
To identify factors contributing to reduced VO2peak in transplant recipients.

Main Methods:

Analysis of VO2peak in patients following renal, liver, heart, and/or lung transplantation.
Investigation of pre- and post-transplant factors affecting exercise capacity.

Main Results:

All common solid-organ transplants show significantly reduced VO2peak (e.g., 50%-80% of predicted).
Pre-transplant VO2peak predicts post-transplant levels; few patients achieve normal ranges.
Skeletal muscle dysfunction, worsened by calcineurin inhibitors, is a major post-transplant limitation.

Conclusions:

Reduced skeletal muscle mass and quality are critical factors limiting exercise capacity post-transplantation.
Immunosuppressive agents like calcineurin antagonists may exacerbate muscle dysfunction.
Skeletal muscle dysfunction is a significant confounder in chronic organ failure recovery post-transplant.