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Origami Inspired Self-assembly of Patterned and Reconfigurable Particles

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pH-responsive self-assembly by molecular recognition on a macroscopic scale.

Yongtai Zheng¹, Akihito Hashidzume, Akira Harada

¹Department of Macromolecular Science, Graduate School of Science, Osaka University, Toyonaka, Osaka 560-0043, Japan.

Macromolecular Rapid Communications

|June 1, 2013

Summary

This summary is machine-generated.

Polyacrylamide gels with dansyl (Dns) and β-cyclodextrin (βCD) residues self-assemble and adhere in response to pH changes. These pH-responsive gels can be controlled for macroscopic assembly and disassembly.

Keywords:

cyclodextrin dansyl molecular recognition pH-responsive self-assembly

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Area of Science:

Polymer Chemistry
Materials Science
Supramolecular Chemistry

Background:

Macroscopic self-assembly is crucial for developing advanced materials.
pH-responsive polymers offer tunable properties for various applications.
Dansyl (Dns) and β-cyclodextrin (βCD) are known for host-guest interactions.

Purpose of the Study:

To construct and characterize macroscopic pH-responsive self-assembly using polyacrylamide (pAAm)-based gels.
To investigate the pH-dependent assembly and disassembly behavior of Dns-gel and βCD-gel.
To quantify the adhesion strength between Dns-gel and βCD-gel as a function of pH.

Main Methods:

Synthesis of polyacrylamide gels functionalized with dansyl (Dns-gel) and β-cyclodextrin (βCD-gel) residues.
Macroscopic assembly/disassembly experiments conducted at varying pH conditions (pH ≥ 4.0 and pH ≤ 3.0).
Adhesion strength measurements for Dns-gel/βCD-gel pairs.
Fluorescence spectroscopy to study the interaction between Dns and βCD in a model pAAm/Dns system.

Main Results:

Dns-gel and βCD-gel demonstrated reversible macroscopic self-assembly and disassembly triggered by pH changes.
Assembly occurred at pH ≥ 4.0, while disassembly was observed at pH ≤ 3.0.
Adhesion strength between Dns-gel and βCD-gel increased with increasing pH.
Fluorescence studies indicated that Dns protonation at lower pH reduces the binding constant with βCD.

Conclusions:

Successfully constructed pH-responsive polyacrylamide gels capable of macroscopic self-assembly.
The pH-dependent behavior is attributed to the protonation of dansyl groups, affecting host-guest interactions with β-cyclodextrin.
These findings open avenues for developing tunable, self-assembling materials controlled by environmental pH.