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Related Experiment Video

Updated: May 11, 2026

Automated High-throughput Behavioral Analyses in Zebrafish Larvae
09:28

Automated High-throughput Behavioral Analyses in Zebrafish Larvae

Published on: July 4, 2013

Zebrafish model systems for developmental neurobehavioral toxicology.

Jordan Bailey1, Anthony Oliveri, Edward D Levin

  • 1Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina 27710, USA.

Birth Defects Research. Part C, Embryo Today : Reviews
|June 1, 2013
PubMed
Summary

Zebrafish are valuable models for studying developmental neurobehavioral toxicology. Behavioral tests in zebrafish reveal the impact of chemical exposures on the developing nervous system.

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Area of Science:

  • Developmental Biology
  • Neuroscience
  • Toxicology

Background:

  • Zebrafish complement mammalian models for studying normal development and teratogenic effects.
  • Their transparent embryos and short maturation times facilitate observation of anatomical and nervous system changes.
  • Increasing demand for zebrafish in behavioral teratology is driven by their developmental, behavioral, and molecular advantages.

Purpose of the Study:

  • To review behavioral tests used in zebrafish for developmental neurobehavioral toxicology.
  • To discuss data from studies examining chemical exposures in zebrafish.
  • To highlight zebrafish as an intermediate model bridging in vitro and mammalian systems.

Main Methods:

  • Development and application of a battery of behavioral tests in zebrafish.

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Related Experiment Videos

Last Updated: May 11, 2026

Automated High-throughput Behavioral Analyses in Zebrafish Larvae
09:28

Automated High-throughput Behavioral Analyses in Zebrafish Larvae

Published on: July 4, 2013

Evaluating Toxicity of Chemicals using a Zebrafish Vibration Startle Response Screening System
06:25

Evaluating Toxicity of Chemicals using a Zebrafish Vibration Startle Response Screening System

Published on: January 12, 2024

Zebrafish Larvae as a Model to Evaluate Potential Radiosensitizers or Protectors
04:53

Zebrafish Larvae as a Model to Evaluate Potential Radiosensitizers or Protectors

Published on: August 25, 2022

  • Evaluation of sensorimotor plasticity, emotional function, cognition, and social interaction.
  • Characterization of adverse effects from developmental exposure to various chemicals.

    • Main Results:

    • Zebrafish behavioral tests effectively measure neurodevelopmental changes.
    • These tests can identify persisting adverse effects of chemical exposures.
    • Zebrafish models provide insights into chemical impacts on behavior.

    Conclusions:

    • Zebrafish are a powerful model for behavioral teratology research.
    • They offer a unique combination of in vitro accessibility and mammalian complexity.
    • Zebrafish facilitate the study of chemical impacts on the developing nervous system.