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A Rat Model of EcoHIV Brain Infection
Published on: January 21, 2021
P300 latency and neurocognitive functioning in recently diagnosed human immunodeficiency virus patients
Ritu Nehra1, Sandeep Grover, Deepak Chetri
1Department of Psychiatry, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Aim:
To assess the P300 latency and amplitude in recently diagnosed human immunodeficiency virus (HIV)-positive patients and compare the same with a healthy control group. Further an attempt was made to study the correlation between P300 amplitude and latency (in milliseconds) with neurocognitive functions.
Materials And Methods:
Thirty newly diagnosed HIV-positive patients who on self report did not have any cognitive dysfunction were recruited. The patients were evaluated for P300 evoked response using the odd-ball paradigm, MMSE and a comprehensive neuropsychological battery. The P300 latencies were compared with 30 normal control subjects.
Results:
The mean P300 latency (in milliseconds) of the HIV-positive subjects was significantly more than the healthy control group. The mean amplitude of HIV group was significantly less than the normal control group. On MMSE, 7 HIV-positive subjects had mild cognitive impairment (MMSE total score 20-23), six patients had minimal cognitive impairment (MMSE total score 24-27) and 17 patients had no cognitive impairment (MMSE total score >27). On neuropsychological test battery only three (10%) of HIV-positive subjects had cognitive dysfunction. There was negative correlation between P300 latency (in milliseconds) and MMSE total score and performance on Koh's Block subtest.
Conclusion:
P300 may be a reliable indicator of cognitive impairments in HIV patients.
