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Updated: May 10, 2026

Neurodevelopmental Reflex Testing in Neonatal Rat Pups
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Neurodevelopmental Reflex Testing in Neonatal Rat Pups

Published on: April 24, 2017

Background data on developmental parameters during the gestation period in rats.

Satoshi Furukawa1, Seigo Hayashi, Masayoshi Abe

  • 1Biological Research Laboratories, Nissan Chemical Industries, Ltd., 1470 Shiraoka, Shiraoka, Saitama 349-0294, Japan.

Journal of Toxicologic Pathology
|June 1, 2013
PubMed
Summary

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Wistar Hannover GALAS rats exhibited lower fetal weights and higher placental labyrinth zone thickness compared to Crl:CD(SD) rats during gestation. These differences in fetal development emerged later in gestation, not during organogenesis.

Area of Science:

  • Reproductive toxicology
  • Comparative animal models
  • Developmental biology

Background:

  • Utilized control group data from 128 Wistar Hannover GALAS and 26 Crl:CD(SD) pregnant rats.
  • Previous toxicity studies provided baseline gestation period data for two rat strains.

Purpose of the Study:

  • To compare fetal and placental development between Wistar Hannover GALAS and Crl:CD(SD) rat strains.
  • Investigate strain-specific differences in maternal weight gain, litter size, and fetal/placental growth dynamics.

Main Methods:

  • Collected body weight and embryonic/fetal data throughout the gestation period.
  • Analyzed placental weight and microscopic features, specifically labyrinth zone thickness.
  • Compared data between Wistar Hannover GALAS and Crl:CD(SD) rat dams and their offspring.
Keywords:
Crl:CD(SD)Wistar Hannover GALASbackground datadevelopmentrat

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Last Updated: May 10, 2026

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Main Results:

  • Wistar Hannover GALAS dams had lower body weights but similar weight gain trends compared to Crl:CD(SD) dams.
  • Wistar Hannover GALAS rats had smaller litter sizes and significantly lower fetal weights on gestation day 21.
  • Placental weights were similar, but the labyrinth zone was thicker in Wistar Hannover GALAS rats throughout gestation.

Conclusions:

  • Fetal weight differences between rat strains manifest later in gestation, post-organogenesis.
  • Placental morphology, specifically labyrinth zone thickness, differs between strains despite similar placental weight.
  • Strain-specific maternal and developmental factors influence fetal growth trajectories.