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Related Experiment Video

Updated: May 10, 2026

Dosimetry for Cell Irradiation using Orthovoltage (40-300 kV) X-Ray Facilities

Dosimetry for Cell Irradiation using Orthovoltage (40-300 kV) X-Ray Facilities

Published on: February 20, 2021

Updated anatomical data and mathematical models for embryo/fetus dosimetry.

¹Department of Health Research, National Institute of Medical Statistics (ICMR), Ansari Nagar, New Delhi, India.

Indian Journal of Nuclear Medicine : IJNM : the Official Journal of the Society of Nuclear Medicine, India

|June 1, 2013

Summary

This study uses mathematical modeling to estimate fetal organ mass during early pregnancy. Findings show total fetal mass is a key predictor for organ mass, crucial for radiation dose calculations in fetal dosimetry.

Keywords:

Fetus organs interpolation mathematical models regression

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A Novel Use of Three-dimensional High-frequency Ultrasonography for Early Pregnancy Characterization in the Mouse

A Novel Use of Three-dimensional High-frequency Ultrasonography for Early Pregnancy Characterization in the Mouse

Published on: October 24, 2017

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Last Updated: May 10, 2026

Dosimetry for Cell Irradiation using Orthovoltage (40-300 kV) X-Ray Facilities

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Published on: February 20, 2021

Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition

Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition

Published on: March 11, 2021

A Novel Use of Three-dimensional High-frequency Ultrasonography for Early Pregnancy Characterization in the Mouse

A Novel Use of Three-dimensional High-frequency Ultrasonography for Early Pregnancy Characterization in the Mouse

Published on: October 24, 2017

Area of Science:

Medical Physics
Developmental Biology
Radiological Science

Background:

Accurate fetal organ mass data is essential for internal radiation dose estimation.
Existing data matrices for fetal mass and volume have gaps, particularly in early gestation.
The Medical Internal Radiation Dose (MIRD) schema has been revised, necessitating updated input parameters.

Purpose of the Study:

To mathematically interpolate and augment existing data on uterine and fetal organ mass/volume from 6 weeks gestation.
To establish relationships between fetal organ mass and predictors like total fetal mass and crown-heel length.
To relate dynamic in-utero growth mass data to the revised MIRD schema for improved fetal dosimetry.

Main Methods:

Numerical interpolation using a 4th-degree polynomial for mass and volume data.
Stepwise regression analysis with placental mass, total fetal mass, and greatest length as predictors.
Utilizing allometric equations to determine the most significant predictors for individual fetal organ masses.

Main Results:

Total fetal mass (Wf) was identified as a more significant predictor (P < 0.001) of fetal organ mass (Wi) than greatest length (H).
Linear and linear-quadratic models based on Wf accurately predicted the mass of various fetal organs.
The brain mass/total mass ratio rapidly decreases from 80% to 39% between 7-9 weeks gestation.

Conclusions:

The dynamic, time-dependent mass of fetal organs is critical for accurate absorbed fraction calculations in fetal dosimetry.
Small target masses and significant variations in organ mass (e.g., fetal thyroid) during early pregnancy can impact absorbed fraction (Φ).
The revised MIRD dose expression, incorporating time-dependent mass, is relevant for fetal dosimetry when source-target distances are considered.