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Related Concept Videos

Changes in Skin Color: Clinical Perspectives01:14

Changes in Skin Color: Clinical Perspectives

The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
Pigmentation01:19

Pigmentation

The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
Acne Infection01:27

Acne Infection

Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...
Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own EpiSCs...
Photoreceptors and Visual Pathways01:22

Photoreceptors and Visual Pathways

At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category, whereas...
Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...

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Related Experiment Video

Updated: May 10, 2026

Using a 1064-nm Picosecond Neodymium-Doped Yttrium Aluminum Garnet Laser for Periorbital Hyperpigmentation
04:43

Using a 1064-nm Picosecond Neodymium-Doped Yttrium Aluminum Garnet Laser for Periorbital Hyperpigmentation

Published on: May 23, 2025

Cosmeceuticals for Hyperpigmentation: What is Available?

Rashmi Sarkar1, Pooja Arora, K Vijay Garg

  • 1Department of Dermatology, Maulana Azad Medical College and Lok Nayak Hospital, New Delhi, India.

Journal of Cutaneous and Aesthetic Surgery
|June 1, 2013
PubMed
Summary
This summary is machine-generated.

Cosmeceuticals offer a safe and effective alternative for treating hyperpigmentation, such as melasma. These skin lightening agents provide health benefits beyond cosmetic enhancement, addressing concerns with traditional therapies.

Keywords:
Cosmeceuticalshyperpigmentationmelasma

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Quantification of Hypopigmentation Activity In Vitro
06:08

Quantification of Hypopigmentation Activity In Vitro

Published on: March 6, 2019

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Last Updated: May 10, 2026

Using a 1064-nm Picosecond Neodymium-Doped Yttrium Aluminum Garnet Laser for Periorbital Hyperpigmentation
04:43

Using a 1064-nm Picosecond Neodymium-Doped Yttrium Aluminum Garnet Laser for Periorbital Hyperpigmentation

Published on: May 23, 2025

Roller Microneedle Combined with Tranexamic Acid Solution in Treating Melasma
04:12

Roller Microneedle Combined with Tranexamic Acid Solution in Treating Melasma

Published on: January 19, 2024

Quantification of Hypopigmentation Activity In Vitro
06:08

Quantification of Hypopigmentation Activity In Vitro

Published on: March 6, 2019

Area of Science:

  • Dermatology and Cosmetic Science
  • Pharmacology of Skin Lightening Agents

Background:

  • Cosmeceuticals, cosmetic-pharmaceutical hybrids, offer health benefits alongside aesthetic improvements.
  • Hyperpigmentation disorders, including melasma and post-inflammatory hyperpigmentation, are challenging to treat.
  • Hydroquinone, a conventional skin lightening agent, raises safety concerns, necessitating alternatives.

Purpose of the Study:

  • To explore alternative cosmeceuticals for hyperpigmentation treatment.
  • To review the safety and efficacy of natural skin lightening agents.
  • To compare cosmeceuticals with conventional hyperpigmentation therapies.

Main Methods:

  • Conducted a literature search on PubMed using keywords: 'cosmeceuticals,' 'hyperpigmentation,' and 'skin lightening agents.'
  • Cited various agents used for treating hyperpigmentation, focusing on melasma and post-inflammatory hyperpigmentation.
  • Described the safety, efficacy, and advantages of alternative cosmeceuticals.

Main Results:

  • Identified several cosmeceutical agents that selectively target hyperplastic melanocytes.
  • These agents inhibit key regulatory steps in melanin synthesis, leading to skin lightening.
  • Highlighted the safety and efficacy of these cosmeceuticals compared to conventional treatments.

Conclusions:

  • Cosmeceuticals represent a promising, safer alternative for managing hyperpigmentation.
  • Natural and effective cosmeceutical options are emerging as viable treatments.
  • These agents offer advantages over traditional therapies for skin lightening.