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Worsened hypertension control induced by aripiprazole
Norio Yasui-Furukori1, Akira Fujii
1Department of Neuropsychiatry, Graduate School of Medicine, Hirosaki University, Hirosaki, Japan.
Neuropsychiatric Disease and Treatment
|June 1, 2013
Summary
Aripiprazole, used for schizophrenia and bipolar disorder, may paradoxically cause hypertension. Two cases showed high blood pressure when switching to aripiprazole, which resolved upon switching back.
Area of Science:
- Psychiatry
- Pharmacology
- Cardiovascular Medicine
Background:
- Aripiprazole is a common antipsychotic for schizophrenia and bipolar disorders.
- Antipsychotics are generally known to lower blood pressure.
- The cardiovascular effects of antipsychotics require ongoing investigation.
Observation:
- Two patients experienced hypertension during medication changes.
- The hypertension occurred specifically when switching to aripiprazole from other antipsychotics.
- Blood pressure normalized after discontinuing aripiprazole and resuming previous medications.
Findings:
- Aripiprazole may be associated with an increased risk of hypertension in some individuals.
- This effect appears to be independent of the typical hypotensive effects of antipsychotics.
- The mechanism by which aripiprazole might induce hypertension warrants further study.
Implications:
- Clinicians should monitor blood pressure in patients initiating or switching to aripiprazole.
- These findings highlight the need for individualized treatment approaches in psychiatric care.
- Further research is needed to understand the prevalence and mechanisms of aripiprazole-induced hypertension.
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