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Updated: May 10, 2026

A General Method for Detecting Nitrosamide Formation in the In Vitro Metabolism of Nitrosamines by Cytochrome P450s
Published on: September 25, 2017
N-{1,2-Bis(pyridin-3-yl)-2-[(E)-(pyridin-3-yl)methyl-idene-amino]-eth-yl}nicotinamide
Claudia M Quiroa-Montalván1, Daniel Chávez, Reyna Reyes-Martínez
1Centro de Graduados e Investigación del Instituto Tecnológico de Tijuana, Apdo. Postal 1166, 22500 Tijuana, BC, Mexico.
Abstract:
In the title compound, C24H20N6O, the pyridin-3-yl groups on the ethyl-ene fragment are found in a trans conformation with a C(py)-C(e)-C(e)-C(py) (py = pyridine, e = ethylene) torsion angle of 179.2 (3)°. The dihedral angle between the pyridine rings is 3.5 (1)°. In the crystal, N-H⋯N and C-H⋯O=C inter-actions form a layer arrangement parallel to the bc plane. The compound displays disorder of the ethyl-ene fragment over two positions with an occupancy ratio of 0.676 (7) to 0.324 (7) that extends into the amide section of the nicotinamide moiety.
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