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Predicting the long-term course of asthma in wheezing infants is still a challenge

Flore Amat1, Amandine Vial, Bruno Pereira

  • 1Asthma and Allergies Centre, Armand-Trousseau Children Hospital, University Pierre and Marie Curie-Paris 6, Paris, France.

ISRN Allergy
|June 1, 2013
PubMed

Insights

Identifying persistent asthma in infants is crucial for management. Allergic sensitization, atopic dermatitis, and severe wheezing are key predictors of asthma continuing into adolescence.

Area of Science:

  • Pediatric Pulmonology
  • Allergy and Immunology

Background:

  • Identifying infants with recurrent wheezing who will develop persistent asthma is vital for effective long-term management strategies.
  • Early identification allows for timely intervention and personalized treatment plans.

Purpose of the Study:

  • To determine predictive factors for persistent asthma at adolescence in infants experiencing recurrent wheezing.
  • To identify key indicators for long-term asthma prognosis in early childhood.

Main Methods:

  • Retrospective study involving 227 infants under 36 months with at least three doctor-assessed wheezing episodes.
  • Utilized the International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire and standardized allergy testing.
  • Assessed active asthma at 13 years of age via questionnaire.

Main Results:

  • Allergic sensitization to multiple airborne allergens (OR 4.6) was a significant predictor.
  • Initial atopic dermatitis (OR 3.4) and severe recurrent wheezing (OR 2.3) were also strongly associated with persistent asthma.
  • Hypereosinophilia (≥470/mm³) was identified as another risk factor (OR 2.2).

Conclusions:

  • While predicting the exact long-term course of childhood asthma remains challenging, atopy is confirmed as a major risk factor for persistence into adolescence.
  • These findings aid in stratifying risk for persistent asthma in wheezy infants.

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