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Related Concept Videos

Autoimmune Disorders01:29

Autoimmune Disorders

Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune system...
Allergic Drug Reactions01:27

Allergic Drug Reactions

Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing numerous...
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Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial exposure to a...
Type I Diabetes I: Introduction01:12

Type I Diabetes I: Introduction

Type 1 diabetes mellitus is a chronic metabolic disorder characterized by an absolute deficiency of insulin resulting from the autoimmune destruction of pancreatic β-cells. Although it can occur at any age, it is most commonly diagnosed in childhood, adolescence, or early adulthood. The loss of insulin production impairs cellular glucose uptake, resulting in persistent hyperglycemia and necessitating lifelong insulin therapy.Autoimmune Destruction of β-CellsThe hallmark of type 1 diabetes is an...
Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin, heparin),...

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Related Experiment Video

Updated: May 10, 2026

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
04:39

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Published on: March 17, 2023

Hormonal link to autoimmune allergies.

Shilpa Shah1

  • 1Division of Science, University of Mumbai, Mumbai 400032, India.

ISRN Allergy
|June 1, 2013
PubMed
Summary

Hormone allergy involves an immune response to the body's own hormones, potentially worsening allergic inflammation. This condition, particularly prevalent in women during their menstrual cycle, shares inflammatory pathways with external allergen reactions.

Area of Science:

  • Immunology
  • Endocrinology
  • Allergy Research

Background:

  • Allergic inflammation can occur without external allergens, involving IgE recognition of autoantigens.
  • Sex hormones may play a role in allergy and autoimmunity, with differing prevalence in males and females across age groups.
  • Hormone allergy is an immune reaction to endogenous hormones, impacting hormone function.

Purpose of the Study:

  • To explore the concept of hormone allergy as a cause of allergic inflammation.
  • To investigate the link between sex hormones and allergic reactions.
  • To understand the characteristics of perimenstrual allergies.

Main Methods:

  • Review of existing literature on allergy, autoimmunity, and hormonal influences.
  • Analysis of the immunological mechanisms involved in hormone allergy.

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Last Updated: May 10, 2026

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
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Published on: March 17, 2023

Preparation of Mouse Pituitary Immunogen for the Induction of Experimental Autoimmune Hypophysitis
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  • Examination of the cyclical nature of hormone allergy, particularly perimenstrual symptoms.

    • Main Results:

    • IgE recognition of autoantigens can drive allergic inflammation intrinsically.
    • Hormone allergy involves an immune response to the body's own hormones.
    • Perimenstrual allergies demonstrate cyclical allergic symptoms linked to hormonal fluctuations.
    • Inflammatory pathways in hormone allergy mirror those in reactions to external allergens.

    Conclusions:

    • Hormone allergy is a distinct allergic condition where endogenous hormones act as allergens.
    • The immune system's response to hormones shares mechanisms with responses to external allergens.
    • Understanding hormone allergy may offer new insights into allergic diseases and autoimmune conditions.