Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Long-term Intracortical Neural activity and Kinematics (LINK): An intracortical neural dataset for chronic brain-machine interfaces, neuroscience, and machine learning.

Advances in neural information processing systems·2026
Same author

Ultrafast oscillations in the human brain and their functional significance.

Epilepsia·2026
Same author

Exploring Synergies in Brain-Machine Interfaces: Compression vs. Performance.

Restorative neurology and neuroscience·2026
Same author

Active electrode location does not influence weight gain after subthalamic nucleus deep brain stimulation surgery in Parkinson disease.

Journal of neural transmission (Vienna, Austria : 1996)·2026
Same author

N-of-1 tissue activation modeling reveals regional subthalamic stimulation predicting verbal fluency decline in Parkinson disease.

Journal of neural transmission (Vienna, Austria : 1996)·2026
Same author

Perturbation-induced responses improved seizure forecasting in epileptic rats.

Epilepsia·2026
Same journal

Letter to the Editor. Enhancing comparability in idiopathic intracranial hypertension research through standardized outcome measures.

Neurosurgical focus·2026
Same journal

Introduction. Contemporary spinal arthroplasty.

Neurosurgical focus·2026
Same journal

Cervical disc arthroplasty as a safe and effective procedure for obese patients.

Neurosurgical focus·2026
Same journal

Comparing the operational metrics and functional outcomes of lumbar arthroplasty implants: a systematic review.

Neurosurgical focus·2026
Same journal

Long-term reoperation risk after cervical disc arthroplasty versus fusion: a level-matched meta-analysis of FDA investigational device exemption studies and international randomized trials.

Neurosurgical focus·2026
Same journal

Total disc replacement versus lumbar interbody fusion for degenerative disc disease: a meta-analysis of randomized controlled trials.

Neurosurgical focus·2026
See all related articles

Related Experiment Video

Updated: May 10, 2026

An Integrated Method for Crafting Flexible and Convenient Electrophysiological Optrodes for Multi-Region In Vivo Recording
06:55

An Integrated Method for Crafting Flexible and Convenient Electrophysiological Optrodes for Multi-Region In Vivo Recording

Published on: November 21, 2024

Optogenetics in epilepsy.

J Nicole Bentley1, Cindy Chestek, William C Stacey

  • 1Department of Neurosurgery, University of Michigan, Ann Arbor, MI 48109, USA.

Neurosurgical Focus
|June 4, 2013
PubMed
Summary
This summary is machine-generated.

Optogenetics uses light to control neural circuits for epilepsy treatment. This method, involving viral delivery of opsins, shows promise in silencing seizure-generating neurons, advancing toward clinical applications.

More Related Videos

Generation and On-Demand Initiation of Acute Ictal Activity in Rodent and Human Tissue
06:45

Generation and On-Demand Initiation of Acute Ictal Activity in Rodent and Human Tissue

Published on: January 19, 2019

Optogenetic Manipulation of Neuronal Activity to Modulate Behavior in Freely Moving Mice
14:40

Optogenetic Manipulation of Neuronal Activity to Modulate Behavior in Freely Moving Mice

Published on: October 27, 2020

Related Experiment Videos

Last Updated: May 10, 2026

An Integrated Method for Crafting Flexible and Convenient Electrophysiological Optrodes for Multi-Region In Vivo Recording
06:55

An Integrated Method for Crafting Flexible and Convenient Electrophysiological Optrodes for Multi-Region In Vivo Recording

Published on: November 21, 2024

Generation and On-Demand Initiation of Acute Ictal Activity in Rodent and Human Tissue
06:45

Generation and On-Demand Initiation of Acute Ictal Activity in Rodent and Human Tissue

Published on: January 19, 2019

Optogenetic Manipulation of Neuronal Activity to Modulate Behavior in Freely Moving Mice
14:40

Optogenetic Manipulation of Neuronal Activity to Modulate Behavior in Freely Moving Mice

Published on: October 27, 2020

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Biotechnology

Background:

  • Optogenetics offers a novel approach to modulate neural activity.
  • Epilepsy treatment remains a significant clinical challenge.

Purpose of the Study:

  • To review the development and application of optogenetics for epilepsy.
  • To explore optogenetics' potential in neurosurgical interventions.

Main Methods:

  • Viral transduction of opsins (algal-derived ion channels) into neurons.
  • Targeting neurons involved in seizure initiation and propagation.
  • Utilizing light to activate or inhibit targeted neural circuits.

Main Results:

  • Optogenetics has shown efficacy in animal models for seizure control.
  • Advancements include studies in nonhuman primate models.
  • The technique allows for precise silencing of specific neural circuits.

Conclusions:

  • Optogenetics is a promising therapeutic strategy for epilepsy.
  • Further research is needed to translate findings to human clinical trials.
  • Optogenetics may significantly impact future neurosurgical approaches for epilepsy.