Related Experiment Video

Updated: May 10, 2026

In Vivo Inhibition of MicroRNA to Decrease Tumor Growth in Mice
07:02

In Vivo Inhibition of MicroRNA to Decrease Tumor Growth in Mice

Published on: August 23, 2019

Complex regulatory network of microRNAs, transcription factors, gene alterations in adrenocortical cancer

Bo Zhang1, Zhi-Wen Xu, Kun-Hao Wang

  • 1Computer Science and Technology Department, Jilin University, Changchun, China. Zhangb999@sina.cn

Asian Pacific Journal of Cancer Prevention : APJCP
|June 4, 2013
PubMed

Insights

This study built a regulatory network to understand gene and microRNA changes in adrenocortical cancer. Key pathways like EGFR showed self-adaptation, offering insights into cancer mechanisms.

Area of Science:

  • Oncology
  • Genomics
  • Systems Biology

Background:

  • Adrenocortical cancer (ACC) is a complex disease.
  • Understanding gene and microRNA alterations is crucial for ACC research.

Purpose of the Study:

  • To construct a regulatory network for adrenocortical cancer.
  • To investigate the roles of transcriptional factors, gene alterations, and microRNAs in ACC development.

Main Methods:

  • Developed three-level networks: differentially expressed, related, and global.
  • Constructed a topology network to model ACC development.
  • Analyzed self-adaptation relations in pathways involving differentially expressed genetic and microRNA elements.

Main Results:

  • Identified key transcriptional factors as central points in the regulatory network.
  • Observed self-adaptation mechanisms in pathways, exemplified by EGFR.
  • Highlighted specific differentially expressed genetic and microRNA elements contributing to ACC.

Conclusions:

  • The constructed network provides a framework for understanding ACC mechanisms.
  • Differentially expressed elements offer potential targets for further research.
  • Findings guide future research into the mechanistic changes driving adrenocortical cancer.

More Related Videos

CRISPR Gene Editing Tool for MicroRNA Cluster Network Analysis10:40

CRISPR Gene Editing Tool for MicroRNA Cluster Network Analysis

Published on: April 25, 2022

Related Concept Videos

mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
Master Transcription Regulators02:23

Master Transcription Regulators

Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a  complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...