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Updated: May 10, 2026

Improving IV Insulin Administration in a Community Hospital
Published on: June 11, 2012
Effects of coverage gap reform on adherence to diabetes medications
Feng Zeng1, Bimal V Patel, Louis Brunetti
1MedImpact Healthcare Systems Inc, San Diego, CA 92131, USA. fzeng@medimpact.com
Objectives:
To investigate the impact of Part D coverage gap reform on diabetes medication adherence.
Study Design:
Retrospective data analysis based on pharmacy claims data from a national pharmacy benefit manager.
Methods:
We used a difference-in-difference-indifference method to evaluate the impact of coverage gap reform on adherence to diabetes medications. Two cohorts (2010 and 2011) were constructed to represent the last year before Affordable Care Act (ACA) reform and the first year after reform, respectively. Each patient had 2 observations: 1 before and 1 after entering the coverage gap. Patients in each cohort were divided into groups based on type of gap coverage: no coverage, partial coverage (generics only), and full coverage.
Results:
Following ACA reform, patients with no gap coverage and patients with partial gap coverage experienced substantial drops in copayments in the coverage gap in 2011. Their adherence to diabetes medications in the gap, measured by percentage of days covered, improved correspondingly (2.99 percentage points, 95% confidence interval [CI] 0.49-5.48, P = .019 for patients with no coverage; 6.46 percentage points, 95% CI 3.34-9.58, P <.0001 for patients with partial coverage). Patients with full coverage also had lower copayments in the gap in 2011. However, their adherence did not increase (-0.13 percentage point, P = .8011).
Conclusions:
In the first year of ACA coverage gap reform, copayments in the gap decreased substantially for all patients. Patients with no coverage and patients with partial coverage in the gap had better adherence in the gap in 2011.
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