Targeting protein-protein interactions as an anticancer strategy.
Andrei A Ivanov1, Fadlo R Khuri, Haian Fu
1Department of Pharmacology, Emory University, Atlanta, GA 30322, USA.
Trends in Pharmacological Sciences
|June 4, 2013
Summary
Targeting protein-protein interactions (PPIs) in cancer is a new therapeutic strategy. Advances in genomics and network oncology enable the development of novel anticancer agents for personalized medicine.
Area of Science:
- Oncology
- Molecular Biology
- Pharmacology
Background:
- Cancer genomics, targeted therapies, and network oncology have expanded the study of protein-protein interaction (PPI) networks for cancer therapeutics.
- Protein interaction hubs and nodes critical for cancer cell transformation are identified as promising therapeutic targets.
- Targeting PPI interfaces has become a viable anticancer strategy due to technological advancements.
Purpose of the Study:
- To review prominent PPIs mediating cancer properties.
- To highlight challenges and clinical results in targeting PPIs.
- To outline emerging opportunities in PPI-based anticancer agent development.
Main Methods:
- Review of biological and clinical investigations.
- Analysis of technological advances in PPI modulator discovery.
- Examination of clinical validation of PPI-targeting agents.
Main Results:
- Identification of key PPIs essential for cancer cell characteristics.
- Demonstration of promising clinical results for PPI-targeting agents.
- Validation of PPI targeting as a realistic anticancer strategy.
Conclusions:
- Genomics-based PPI target discovery and interface characterization are crucial.
- PPI-focused chemical libraries and patient-driven studies will advance personalized medicine.
- Targeting PPIs represents a significant opportunity for next-generation anticancer agents.
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