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Modeling and Evaluation of Murine Diabetic Cardiomyopathy Model
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The limited clinical value of a specific diabetic cardiomyopathy

S Vigili de Kreutzenberg1, A Avogaro

  • 1Department of Medicine DIMED, University of Padova, Via Giustiniani 2, 35128 Padova, Italy. saula.dekreutzenberg@unipd.it

Nutrition, Metabolism, and Cardiovascular Diseases : NMCD
|June 4, 2013
PubMed

Insights

Diabetic patients have an intrinsic heart vulnerability, leading to a higher risk of heart failure (HF) independent of atherosclerosis. This review covers diabetic cardiomyopathy (DCM) pathophysiology, diagnosis, and treatment.

Area of Science:

  • Cardiology
  • Endocrinology
  • Metabolic Diseases

Background:

  • Diabetic patients exhibit increased susceptibility to heart failure (HF), irrespective of atherosclerotic disease, indicating intrinsic cardiac vulnerability.
  • Diabetic cardiomyopathy (DCM) was first proposed in 1972 and recognized by the WHO in 1995, affecting patients with diabetic glomerulosclerosis but without significant coronary artery disease (CAD).

Purpose of the Study:

  • To review recent pathophysiological findings and diagnostic strategies for diabetic cardiomyopathy (DCM).
  • To focus on the clinical manifestation of DCM as heart failure (HF) and the impact of comorbidities and metabolic control on its progression.

Main Methods:

  • Literature review of pathophysiological mechanisms, clinical manifestations, and therapeutic approaches for DCM.
  • Analysis of studies in both animal models and human subjects.

Main Results:

  • Despite extensive research, the precise clinical significance and entity of DCM remain incompletely understood.
  • High plasma glucose levels (mean 417 ± 209 mg/dl) were noted in early DCM cases.

Conclusions:

  • Diabetic cardiomyopathy (DCM) represents a significant complication of diabetes mellitus, manifesting as heart failure (HF).
  • Understanding the interplay of comorbidities and metabolic control is crucial for managing DCM progression and treatment.
Abstract

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