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Wuling san ameliorates urate under-excretion and renal dysfunction in hyperuricemic mice
Xiao-Qin Ding1, Ying Pan, Xing Wang
1State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, China.
Chinese Journal of Natural Medicines
|June 4, 2013
Summary
Wuling San effectively lowers uric acid and improves kidney function in hyperuricemic mice by enhancing urate excretion and modulating key renal transporters. This traditional remedy demonstrates significant therapeutic potential for managing hyperuricemia.
Area of Science:
- Pharmacology and Traditional Chinese Medicine
- Nephrology and Metabolic Disorders
Background:
- Hyperuricemia is a condition characterized by elevated serum uric acid levels, increasing the risk of gout and kidney disease.
- Understanding the mechanisms by which traditional remedies like Wuling San impact urate homeostasis is crucial for developing novel therapeutic strategies.
Purpose of the Study:
- To investigate the effects of Wuling San on urate excretion and renal function in a mouse model of hyperuricemia.
- To elucidate the molecular mechanisms underlying Wuling San's action on renal urate transporters.
Main Methods:
- A hyperuricemia mouse model was established using potassium oxonate.
- Mice were treated with varying doses of Wuling San or allopurinol (positive control).
- Serum and urine uric acid, creatinine, fractional excretion of uric acid (FEUA), and renal transporter expression (mURAT1, mGLUT9, mOAT1, mOCT1, mOCT2, mOCTN2) were analyzed.
Main Results:
- Wuling San significantly reduced serum uric acid and creatinine levels.
- Treatment with Wuling San increased 24-hour urate and creatinine excretion, as well as FEUA.
- Wuling San modulated the expression of renal urate transporters, down-regulating mURAT1 and mGLUT9, and up-regulating mOAT1, mOCT1, mOCT2, and mOCTN2.
Conclusions:
- Wuling San demonstrates efficacy in enhancing urate excretion and improving renal function in hyperuricemic mice.
- The herb acts by modulating the expression of critical renal urate and organic ion transporters.
- These findings support Wuling San's potential as a therapeutic agent for hyperuricemia and related kidney conditions.
