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Related Concept Videos

Pharmacogenomics: Identification of New Drug Targets01:29

Pharmacogenomics: Identification of New Drug Targets

Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
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Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...

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Cost-Efficient Transcriptomic-Based Drug Screening
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Published on: February 23, 2024

Single-cell transcriptomics for drug target discovery.

Jennifer M Spaethling1, James H Eberwine

  • 1Department of Pharmacology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Current Opinion in Pharmacology
|June 4, 2013
PubMed
Summary
This summary is machine-generated.

Single cell sequencing is rapidly advancing, offering new insights into cell variability and potential drug targets. Ongoing improvements in methods and technology enhance data quality and accessibility for researchers.

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A Combinatorial Single-cell Approach to Characterize the Molecular and Immunophenotypic Heterogeneity of Human Stem and Progenitor Populations

Published on: October 25, 2018

Area of Science:

  • Genomics
  • Molecular Biology
  • Biotechnology

Background:

  • Single cell sequencing is an emerging field generating vast amounts of biological data.
  • It provides insights into intercellular variability and aids in identifying novel drug targets.
  • Technological advancements are continuously improving data generation and accessibility.

Purpose of the Study:

  • To highlight the current state and advancements in single cell sequencing.
  • To emphasize the impact of single cell sequencing on biological research and drug discovery.
  • To discuss the ongoing development of techniques and tools in the field.

Main Methods:

  • Improvements in sample preparation, including in vivo pipette techniques.
  • Advancements in sequencing platforms such as Illumina HiSeq/MiSeq, Ion Torrent PGM, and Pacific Biosciences RS.
  • Development of new bioinformatics tools for data analysis.

Main Results:

  • Unprecedented amounts of data are being generated through single cell sequencing.
  • New insights into intercellular variability are being uncovered.
  • Previously unrecognized drug targets are being identified.

Conclusions:

  • Single cell sequencing technologies are rapidly evolving, enhancing data quality and quantity.
  • These advancements are making complex biological questions more accessible to researchers.
  • The field holds significant promise for future biological and medical research.