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Updated: May 10, 2026
18:48
Murine Renal Transplantation Procedure
Published on: July 10, 2009
Infectious complications in the first year post renal transplantation
G Kosmadakis1, G L Daikos, I D Pavlopoulou
1Renal Transplant Unit, Laiko Hospital, Athens, Greece. George.kosmadakis@gmail.com
Transplantation Proceedings
|June 4, 2013
Summary
Infections are common in the first year after renal transplantation (Rtx). Diabetes and specific immunosuppressive drugs increase infection risk, while urinary tract infections (UTI) and cytomegalovirus (CMV) are frequent post-transplant complications.
Area of Science:
- Nephrology
- Transplant Surgery
- Infectious Diseases
Background:
- Infections pose a significant threat to renal transplant recipients (Rtr).
- Understanding risk factors for post-transplant infections is crucial for patient outcomes.
Purpose of the Study:
- To prospectively assess and identify risk factors for infections in Rtr during the first year after renal transplantation (Rtx).
Main Methods:
- A prospective study involving 133 Rtx procedures.
- Data collected on patient demographics, immunosuppressive regimens, and infection episodes.
- Statistical analysis to determine risk factors for infections.
Main Results:
- 45% of patients experienced infectious episodes within the first year post-Rtx.
- Urinary tract infections (UTI) were the most common (61%), followed by cytomegalovirus (CMV) and fungal infections.
- Diabetes (OR 1.154) and specific immunosuppressive regimens (OR 3.053) were significant risk factors for infection. Increased CMV risk was noted post-chemoprophylaxis (OR 0.456).
Conclusions:
- The primary disease of the Rtr and the chosen immunosuppressive regimen significantly influence infection rates.
- UTI is the most frequent infection, particularly in the first three months post-Rtx.
- A higher risk of CMV infection exists after the chemoprophylaxis period concludes.
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