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Drug and alcohol trajectories among adults with schizophrenia: data from the CATIE study
Richard A Van Dorn1, Sarah L Desmarais, Stephen J Tueller
1RTI International, 3040 E. Cornwallis Road, P.O. Box 12194, Research Triangle Park, NC 27709, United States. rvandorn@rti.org
Objective:
The primary aim is to describe drug and alcohol trajectories in adults with schizophrenia.
Method:
Growth mixture models were used to examine disordered and non-disordered use and abstinence in the Clinical Antipsychotic Trials of Intervention Effectiveness study.
Results:
Five classes - always abstinent; fluctuating use, abuse, and occasional abstinence; occasional (ab)use; stopped (ab)use; abusing - fit best. Overlap exists between always abstinent drug and alcohol classes; less overlap exists across other classes.
Conclusion:
There is heterogeneity in drug and alcohol use among adults with schizophrenia. The lack of overlap between classes, save always abstinent, suggests modeling drug and alcohol use separately.
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