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Related Experiment Video

Updated: May 10, 2026

Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging
09:14

Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging

Published on: March 14, 2025

Altered affective processing in bipolar disorder: an fMRI study.

Kelly A Sagar1, Mary Kathryn Dahlgren, Atilla Gönenç

  • 1Cognitive and Clinical Neuroimaging Core, Brain Imaging Center, McLean Hospital, Belmont, MA 02478, USA.

Journal of Affective Disorders
|June 4, 2013
PubMed
Summary
This summary is machine-generated.

Patients with bipolar disorder (BPD) show altered brain activity in key emotional processing regions. This may explain difficulties in recognizing social cues, particularly fear.

Keywords:
Affective processingAmygdalaBipolar disorderCingulateEmotionfMRI

More Related Videos

Brain Imaging Investigation of the Impairing Effect of Emotion on Cognition
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Brain Imaging Investigation of the Impairing Effect of Emotion on Cognition

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Related Experiment Videos

Last Updated: May 10, 2026

Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging
09:14

Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging

Published on: March 14, 2025

Brain Imaging Investigation of the Impairing Effect of Emotion on Cognition
16:08

Brain Imaging Investigation of the Impairing Effect of Emotion on Cognition

Published on: February 1, 2012

Area of Science:

  • Neuroscience
  • Psychiatry
  • Affective Science

Background:

  • Bipolar disorder (BPD) is associated with inconsistent findings regarding emotional processing and regulation.
  • Previous research highlights the need for further investigation into affective processing in BPD.

Purpose of the Study:

  • To investigate affective processing in patients diagnosed with Bipolar I Disorder (BPD).
  • To explore neural correlates of emotional processing in BPD using functional magnetic resonance imaging (fMRI).

Main Methods:

  • fMRI was used to study 23 BPD patients and 18 healthy controls during a backward-masked affect paradigm.
  • Participants also completed a facial emotion discrimination task post-scanning.

Main Results:

  • BPD patients exhibited altered amygdala, anterior cingulate cortex (ACC), and dorsolateral prefrontal cortex (DLPFC) responses to happy and fearful stimuli.
  • BPD participants demonstrated significant deficits in identifying fearful facial affect.

Conclusions:

  • Altered affective processing in BPD may lead to difficulties in interpreting social cues.
  • Findings suggest implications for social functioning in individuals with BPD.