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Updated: May 10, 2026

Assessment of Child Anthropometry in a Large Epidemiologic Study
09:36

Assessment of Child Anthropometry in a Large Epidemiologic Study

Published on: February 2, 2017

A systematic review of statistical methods used in constructing pediatric reference intervals.

Caitlin H Daly1, Xiaofeng Liu, Vijay L Grey

  • 1Clinical Epidemiology and Biostatistics, McMaster University, Canada.

Clinical Biochemistry
|June 4, 2013
PubMed
Summary

Current methods for establishing pediatric reference intervals have significant gaps, particularly in partitioning techniques and handling small sample sizes. Standardized guidelines are needed to improve accuracy and capture the dynamic nature of pediatric data.

Keywords:
BMIBody Mass IndexCALIPERCHILDxCLSICanadian Laboratory Initiative in Pediatric Reference IntervalsChildren's Health Improvement Through Laboratory DiagnosticsClinical and Laboratory Standards InstituteGerman Health Interview and Examination Survey for Children and AdolescentsKiGGSLOOKLifestyle Of Our KidsPediatricREBReference intervalReference limitReference valueResearch Ethics BoardStatistical methods

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Last Updated: May 10, 2026

Assessment of Child Anthropometry in a Large Epidemiologic Study
09:36

Assessment of Child Anthropometry in a Large Epidemiologic Study

Published on: February 2, 2017

Area of Science:

  • Clinical Chemistry
  • Biostatistics
  • Pediatric Medicine

Background:

  • Establishing accurate pediatric reference intervals is crucial for diagnosing and monitoring health conditions in children.
  • Existing methodologies for reference interval estimation often lack standardization and may not adequately address the unique characteristics of pediatric data.

Purpose of the Study:

  • To systematically review statistical methods used in the construction of pediatric reference intervals.
  • To identify current gaps and limitations in the estimation and reporting of pediatric reference intervals.

Main Methods:

  • A systematic review of medical literature was conducted.
  • Searches were performed on Embase, Medline, and PubMed using extensive criteria.
  • Articles were screened based on predefined inclusion and exclusion criteria.

Main Results:

  • Significant gaps exist in the methodology and reporting of pediatric reference intervals.
  • Inconsistent adherence to Clinical and Laboratory Standards Institute (CLSI) guidelines was observed.
  • Methodological variations and discrepancies were noted, especially for small sample sizes and when capturing the dynamic nature of pediatric data.

Conclusions:

  • Current pediatric reference interval development requires improvements in partitioning methods to reduce subjectivity and enhance representativeness.
  • Addressing challenges with small sample sizes and the dynamic nature of pediatric data is essential.
  • The development of a pediatric-specific guideline for establishing reference intervals is strongly recommended to ensure standardization and precision.