Reference intervals for serum creatinine levels in the healthy geriatric population

Area of Science:

• Geriatric Medicine
• Clinical Chemistry
• Nephrology

Background:

• Limited reference values for serum creatinine (Scr) in healthy elderly populations.
• Need for age- and sex-specific Scr reference intervals (RIs).

Purpose of the Study:

• Establish reliable RIs for enzymatically assayed Scr in healthy Chinese Han elderly.
• Provide updated clinical and laboratory reference points for geriatric care.

Main Methods:

• Recruited healthy Chinese Han individuals aged 60-89 years.
• Stratified participants by gender and age groups (60-69, 70-79, 80-89).
• Measured Scr using an enzymatic method and determined 95th percentile RIs via non-parametric statistics.

Main Results:

• Serum creatinine values showed Gaussian distribution with age and sex differences.
• Established RIs for males (60-69: 52.9-94.5; 70-79: 57.3-106.2; 80-89: 59.0-110.8 μmol/L).
• Established RIs for females (60-69: 44.3-75.4; 70-79: 47.1-85.5; 80-89: 45.1-90.9 μmol/L).

Conclusions:

• Successfully established Scr RIs for the healthy Chinese Han elderly using an enzymatic method.
• These RIs are valuable for clinical diagnosis and laboratory assessments in geriatric populations.