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Related Concept Videos

Diversity of Protists I01:15

Diversity of Protists I

Excavata is a diverse group of protists that includes both chemoorganotrophic and phototrophic species, with some thriving in anaerobic environments. Among the key groups within Excavata are diplomonads and parabasalids, which are flagellated protists that lack mitochondria and chloroplasts. These microorganisms typically inhabit anoxic environments, such as the intestines of animals, where they exist either symbiotically or as parasites, relying on fermentation for energy production. Some...
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Parasitism is a form of microbial interaction in which parasitic microbes exploit a host organism for nutrients and shelter, often at the host's expense. Unlike mutualistic relationships, where both organisms benefit, parasitism benefits only the parasite and harms the host.Classification of ParasitesMicrobial parasites are broadly classified based on their location relative to the host.Ectoparasites remain on the host’s surface, such as the skin or outer tissues, drawing nutrients...
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Updated: May 10, 2026

Discovery of New Intracellular Pathogens by Amoebal Coculture and Amoebal Enrichment Approaches
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Published on: October 27, 2013

Giardia: both a harmless commensal and a devastating pathogen.

Herbert L DuPont1

  • 1University of Texas School of Public Health and Medical School, St. Luke's Episcopal Hospital, Baylor College of Medicine, and Kelsey Research Foundation, Houston, Texas, USA. Herbert.L.Dupont@uth.tmc.edu

The Journal of Clinical Investigation
|June 4, 2013
PubMed
Summary

Giardia lamblia infection can cause severe diarrhea and growth issues, especially when combined with malnutrition. A new mouse model helps explain these effects and suggests therapeutic strategies.

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Tractable Mammalian Cell Infections with Protozoan-primed Bacteria
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Discovery of New Intracellular Pathogens by Amoebal Coculture and Amoebal Enrichment Approaches
09:04

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Tractable Mammalian Cell Infections with Protozoan-primed Bacteria
13:54

Tractable Mammalian Cell Infections with Protozoan-primed Bacteria

Published on: April 2, 2013

Area of Science:

  • Infectious Diseases
  • Gastroenterology
  • Nutritional Science

Background:

  • Giardia lamblia is a common protozoan parasite causing enteritis.
  • Infection outcomes range from asymptomatic to severe diarrhea and morbidity.
  • The impact of malnutrition on symptomatic Giardia infection requires further elucidation.

Purpose of the Study:

  • To establish a mouse model for Giardia lamblia infection.
  • To investigate the role of malnutrition in the development of symptomatic Giardia infection.
  • To understand the mechanisms linking Giardia infection to growth retardation.

Main Methods:

  • Development of a novel mouse model for Giardia lamblia infection.
  • Co-administration of Giardia lamblia and nutritional deficiencies in the mouse model.
  • Assessment of infection severity, host response, and growth parameters.

Main Results:

  • The mouse model recapitulates key features of human Giardia infection.
  • Coincident malnutrition exacerbates symptomatic infection and impairs growth.
  • Specific host-pathogen interactions contributing to growth retardation were identified.

Conclusions:

  • The developed mouse model is valuable for studying Giardia lamblia pathogenesis.
  • Malnutrition significantly contributes to the severity of Giardia infection and associated growth deficits.
  • Findings provide insights for developing targeted therapeutic strategies for Giardia infections, particularly in malnourished populations.