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Updated: May 10, 2026

Arbovirus Infections As Screening Tools for the Identification of Viral Immunomodulators and Host Antiviral Factors
Published on: September 13, 2018
Systems virology: host-directed approaches to viral pathogenesis and drug targeting
G Lynn Law1, Marcus J Korth, Arndt G Benecke
1Department of Microbiology and Washington National Primate Research Center, University of Washington, Box 358070, Seattle, Washington 98195, USA.
Abstract:
High-throughput molecular profiling and computational biology are changing the face of virology, providing a new appreciation of the importance of the host in viral pathogenesis and offering unprecedented opportunities for better diagnostics, therapeutics and vaccines. Here, we provide a snapshot of the evolution of systems virology, from global gene expression profiling and signatures of disease outcome, to geometry-based computational methods that promise to yield novel therapeutic targets, personalized medicine and a deeper understanding of how viruses cause disease. To realize these goals, pipettes and Petri dishes need to join forces with the powers of mathematics and computational biology.
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