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Updated: May 10, 2026
A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis
Published on: March 8, 2022
Melanoma metastasis: new concepts and evolving paradigms
W E Damsky1, N Theodosakis2, M Bosenberg2
11] Department of Dermatology, Yale University School of Medicine, New Haven, CT, USA [2] Department of Pathology, University of Vermont College of Medicine, Burlington, VT, USA.
Abstract:
Melanoma progression is typically depicted as a linear and stepwise process in which metastasis occurs relatively late in disease progression. Significant evidence suggests that in a subset of melanomas, progression is much more complex and less linear in nature. Epidemiologic and experimental observations in melanoma metastasis are reviewed here and are incorporated into a comprehensive model for melanoma metastasis, which takes into account the varied natural history of melanoma formation and progression.
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