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Updated: May 10, 2026

Determination of the Gas-phase Acidities of Oligopeptides
Published on: June 24, 2013
Electron capture dissociation and collision induced dissociation of S-dipalmitoylated peptides
Małgorzata A Kaczorowska1, Helen J Cooper
1Faculty of Chemical Technology and Engineering, University of Technology and Life Sciences in Bydgoszcz, Seminaryjna 3, Bydgoszcz, Poland. Malgorzata.Kaczorowska@utp.edu.pl
Abstract:
Here we investigate the effect of S-dipalmitoylation on the electron capture dissociation (ECD) behavior of peptides. The ECD and collision induced dissociation (CID) of peptides modified by covalent attachment of [(RS)-2,3-di(palmitoyloxy)-propyl] (PAM2) group to cysteine residues [C(PAM2)LEYDTGFK and RPPGC(PAM2)SPFK] were examined. The results suggest that ECD of S-dipalmitoylated peptides can provide both primary sequence information and structural information regarding the modification. The structural information provided by CID is complementary to that provided by ECD.
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