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Updated: May 10, 2026
09:14
Pre-Chiasmatic, Single Injection of Autologous Blood to Induce Experimental Subarachnoid Hemorrhage in a Rat Model
Published on: June 18, 2021
Early versus delayed mobilisation for aneurysmal subarachnoid haemorrhage
Zhenxing Ma1, Qiuxiao Wang, Ming Liu
1Department of Neurology, West China Hospital, Sichuan University, Chengdu, China.
The Cochrane Database of Systematic Reviews
|June 4, 2013
Summary
Early mobilization in aneurysmal subarachnoid hemorrhage (SAH) patients without surgery lacks evidence. Current research cannot confirm if early movement reduces rebleeding deaths compared to prolonged bedrest.
Area of Science:
- Neurology
- Neurosurgery
- Critical Care Medicine
Background:
- Rebleeding is a major cause of death and disability following aneurysmal subarachnoid hemorrhage (SAH).
- Aneurysm ablation is the preferred treatment, but some patients are ineligible for surgery or opt for conservative management.
- Prolonged bedrest (4-6 weeks) is a traditional intervention, yet its impact on SAH outcomes remains unclear.
Purpose of the Study:
- To determine if early mobilization (less than 4 weeks post-onset) versus delayed mobilization (at least 4 weeks post-onset) impacts rebleeding mortality in non-surgically treated aneurysmal SAH patients.
Main Methods:
- A systematic search of multiple databases (Cochrane Stroke Group, CENTRAL, MEDLINE, EMBASE, etc.) was conducted up to June 2012.
- The review planned to include randomized controlled trials (RCTs) comparing early mobilization with delayed mobilization.
- Trial selection and data extraction were performed independently by two reviewers.
Main Results:
- No suitable RCTs were identified, precluding meta-analysis.
- Observational data suggest the highest risk of rebleeding occurs early, particularly within 24 hours of SAH.
- The effect of bedrest on aneurysm management requires further investigation.
Conclusions:
- There is a lack of RCT evidence to support or refute the practice of prolonged bedrest (≥4 weeks) for non-surgically treated aneurysmal SAH patients.
- Developing treatment strategies to mitigate rebleeding risk in these patients is crucial.
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