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Related Experiment Video

Updated: May 10, 2026

Utilizing Repetitive Transcranial Magnetic Stimulation to Improve Language Function in Stroke Patients with Chronic Non-fluent Aphasia
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Utilizing Repetitive Transcranial Magnetic Stimulation to Improve Language Function in Stroke Patients with Chronic Non-fluent Aphasia

Published on: July 2, 2013

Repetitive transcranial magnetic stimulation for improving function after stroke.

Zilong Hao1, Deren Wang, Yan Zeng

  • 1Department of Neurology, West China Hospital, Sichuan University, Chengdu, China.

The Cochrane Database of Systematic Reviews
|June 4, 2013
PubMed
Summary
This summary is machine-generated.

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Repetitive transcranial magnetic stimulation (rTMS) did not significantly improve function in stroke survivors. More research is needed to determine if rTMS is effective for stroke rehabilitation.

Area of Science:

  • Neuroscience
  • Rehabilitation Medicine
  • Clinical Trials

Background:

  • Previous assumptions suggested repetitive transcranial magnetic stimulation (rTMS) could aid stroke recovery by modulating motor cortex excitability.
  • The study aimed to evaluate the effectiveness and safety of rTMS in stroke patients.

Purpose of the Study:

  • To assess the efficacy and safety of repetitive transcranial magnetic stimulation (rTMS) for improving function in individuals who have had a stroke.

Main Methods:

  • A comprehensive literature search was conducted across multiple databases including Cochrane Stroke Group Trials Register, CENTRAL, MEDLINE, EMBASE, and others.
  • Included were 19 randomized controlled trials (RCTs) with 588 participants comparing rTMS therapy to sham therapy or no therapy.
  • Data extraction and quality assessment were performed independently by two reviewers.

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Last Updated: May 10, 2026

Utilizing Repetitive Transcranial Magnetic Stimulation to Improve Language Function in Stroke Patients with Chronic Non-fluent Aphasia
10:15

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Published on: July 2, 2013

Repetitive Transcranial Magnetic Stimulation to the Unilateral Hemisphere of Rat Brain
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Repetitive Transcranial Magnetic Stimulation to the Unilateral Hemisphere of Rat Brain

Published on: October 22, 2016

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Localizing Function-specific Targets for Transcranial Magnetic Stimulation in the Absence of Navigation Equipment

Published on: May 23, 2025

Main Results:

  • rTMS treatment did not show a significant increase in Barthel Index scores (MD 15.92, 95% CI -2.11 to 33.95) in 183 participants across two trials.
  • Motor function improvements were not statistically significant in four trials involving 73 participants (SMD 0.51, 95% CI -0.99 to 2.01).
  • Mild adverse events like headaches and local discomfort were reported, with no significant differences observed across stimulation frequencies or illness durations.

Conclusions:

  • Current evidence does not support the routine application of repetitive transcranial magnetic stimulation (rTMS) for stroke treatment.
  • Further large-scale trials are necessary to establish optimal rTMS protocols and long-term functional outcomes for stroke rehabilitation.