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Application of Laparoscopic Hepatectomy Combined with Intraoperative Microwave Ablation in Colorectal Cancer Liver Metastasis

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Electro-coagulation for liver metastases.

Robert P Riemsma¹, Malgorzata M Bala, Robert Wolff

¹Kleijnen Systematic Reviews Ltd, York, UK. rob@systematic-reviews.com.

The Cochrane Database of Systematic Reviews

|June 4, 2013

Summary

This summary is machine-generated.

Electro-coagulation alone did not significantly improve survival for liver metastases from colorectal cancer. Adding allopurinol or dimethyl sulphoxide showed some benefit, but more research is needed due to trial limitations.

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Assessment of Plasma Coagulation on Liver Tissue in a Large Animal Model In Vivo

Assessment of Plasma Coagulation on Liver Tissue in a Large Animal Model In Vivo

Published on: August 4, 2018

Area of Science:

Oncology
Surgical Oncology
Gastroenterology

Background:

Liver metastases from colorectal carcinoma are common and often fatal.
Electro-coagulation aims to destroy liver tumours using electrical current.
This study evaluates electro-coagulation for liver metastases.

Purpose of the Study:

To assess the benefits and harms of electro-coagulation versus no intervention, other ablation methods, or systemic treatments for liver metastases.

Main Methods:

Searched multiple databases up to December 2012.
Included one randomized clinical trial comparing electro-coagulation alone, with allopurinol, with dimethyl sulphoxide, and a control group.
Extracted data on participant characteristics, interventions, and outcomes; risk of bias was assessed.

Main Results:

The single included trial had a high risk of bias.
Electro-coagulation alone showed no significant survival benefit compared to the control.
Adding allopurinol or dimethyl sulphoxide to electro-coagulation demonstrated a significant survival benefit.

Conclusions:

Insufficient evidence exists to support electro-coagulation alone for liver metastases due to trial limitations.
Evidence for adding allopurinol or dimethyl sulphoxide is also insufficient.
Further randomized trials are necessary to validate electro-coagulation's effectiveness.