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Updated: Aug 6, 2026

High Content Screening Analysis to Evaluate the Toxicological Effects of Harmful and Potentially Harmful Constituents (HPHC)
Published on: May 10, 2016
Non-mutagenic carcinogens are primarily hydrophobic
G D McCoy1, H S Rosenkranz, G Klopman
1Department of Environmental Health Sciences, Case Western Reserve University, Cleveland, OH 44106.
Abstract:
There is no unique mechanism to explain the activity in animals of 'non-genotoxic' carcinogens. In this they differ from 'genotoxic' carcinogens that are DNA reactive. In the present study it is reported that non-mutagenic carcinogens, as a group, have significantly higher computed octanol/water partition coefficients than mutagenic ones. This property of non-mutagenic carcinogens may suggest that their ability to induce tumors is associated with membraneous receptor sites and/or a longer residence time in the animal.
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