Related Experiment Video
Updated: May 10, 2026
A Nonviral Approach to Generate Transient Chimeric Antigen Receptor T Cells Using mRNA for Cancer Immunotherapy
Published on: February 21, 2025
Risk of second primary malignancies after nasopharyngeal carcinoma: a population-based cohort study in Taiwan
Charlene Lin1, Shih-Wei Lin, Shih-Feng Weng
1Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California.
Background:
The purpose of this study was to examine the risk of second primary malignancy (SPM) after nasopharyngeal carcinoma (NPC).
Methods:
We compared the incidence of SPM in patients diagnosed with NPC at the end of 2009 using the data extracted from the Taiwan Longitudinal Health Insurance Database between 2001 and 2008 (n = 10,299), with age-matched controls (1:10; n = 102,990).
Results:
We found a 55% increased risk of SPM in patients diagnosed with NPC, compared to the risk of first malignancy in the age-matched controls (incidence rate ratio [IRR] = 1.55; p < .0001). Although the diagnosis of SPM was negatively correlated with the survival of patients with NPC (p = .0011), primary NPC did not display any synergic effect on the survival of patients with SPM, compared to age-matched controls with a newly diagnosed malignancy (p = .8986).
Conclusion:
NPC is associated with an increased risk of developing an SPM.