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Updated: May 10, 2026

An R-Based Landscape Validation of a Competing Risk Model
Published on: September 16, 2022
NONPARAMETRIC BENCHMARK ANALYSIS IN RISK ASSESSMENT: A COMPARATIVE STUDY BY SIMULATION AND DATA ANALYSIS
Rabi Bhattacharya1, Lizhen Lin
1Department of Mathematics, The University of Arizona, Tucson, AZ, 85721, USA.
Abstract:
We consider the finite sample performance of a new nonparametric method for bioassay and benchmark analysis in risk assessment, which averages isotonic MLEs based on disjoint subgroups of dosages, and whose asymptotic behavior is essentially optimal (Bhattacharya and Lin (2010)). It is compared with three other methods, including the leading kernel-based method, called DNP, due to Dette et al. (2005) and Dette and Scheder (2010). In simulation studies, the present method, termed NAM, outperforms the DNP in the majority of cases considered, although both methods generally do well. In small samples, NAM and DNP both outperform the MLE.
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