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Published on: October 24, 2025
Granulosa cell tumours: a study of 37 cases
C Nirmala1, Kalpana S Dave, Anjana Chauhan
1Gujarat Cancer and Research Institute, New Civil Hospital Campus, Asarva, Ahmedabad, 380016 India ; No. 91, III Cross, New Timber Yard Layout, Telecom Colony, Bangalore, 560026 India.
Objectives:
To evaluate the clinico-pathological features, surgical procedures and postoperative treatment and their relation to survival in women with granulosa cell tumours.
Methods:
Data of 37 women with granulosa cell tumours were collected and reviewed retrospectively. Mann-Whitney test, log rank test and Kaplan-Meier survival analysis were applied appropriately.
Results:
Thirty-seven women of median age 48.6 years were diagnosed in stage Ia (45.9 %), stage Ic (27 %), stage III (16.2 %) and unstaged (10.8 %). The median follow up was 5 years. Overall survival was 93 % at 5 years. Disease-free survival at 5 years was 63 %. Tumour stage and residual disease were associated with poor prognosis (p < 0.001). Mitotic rate and tumour grade were not of prognostic significance.
Conclusions:
Stage of disease and residual disease are valuable prognostic factors. Prospective studies with large sample sizes and long-term follow up are needed to confirm our findings.