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Updated: May 10, 2026
09:25
ROS Live Cell Imaging During Neuronal Development
Published on: February 9, 2021
NADPH oxidase and neurodegeneration
Marina S Hernandes1, Luiz R G Britto
1Departamento de Fisiologia e Biofísica, Instituto de Ciências Biomédicas and Núcleo de Apoio à Pesquisa em Neurociência Aplicada, Universidade de São Paulo, SP, Brasil.
Current Neuropharmacology
|June 5, 2013
Summary
NADPH oxidase (Nox) enzymes generate superoxide, contributing to oxidative stress in neurodegenerative diseases like Parkinson's and Alzheimer's. This review explores Nox's role in these conditions.
Area of Science:
- Biochemistry
- Neuroscience
- Cell Biology
Background:
- NADPH oxidase (Nox) is an enzyme complex generating superoxide.
- Nox-derived reactive oxygen species (ROS) are implicated in physiological processes.
- Growing evidence links Nox-dependent oxidative stress to neurodegenerative disease pathology.
Purpose of the Study:
- To review recent literature on the involvement of Nox enzymes in neurodegeneration.
- To focus on the role of Nox in Parkinson and Alzheimer diseases.
Main Methods:
- Literature review of scientific articles.
- Analysis of studies investigating Nox enzymes and oxidative stress.
- Focus on research related to Parkinson and Alzheimer diseases.
Main Results:
- Nox proteins produce ROS that contribute to neurodegeneration.
- Mechanisms include oxidation of cellular components and activation of signaling pathways.
- Nox involvement is increasingly recognized in Parkinson and Alzheimer diseases.
Conclusions:
- Nox-dependent oxidative stress is a significant factor in neurodegenerative diseases.
- Understanding Nox pathways is crucial for therapeutic strategies.
- Further research is needed to fully elucidate Nox's role in neurodegeneration.
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