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Updated: May 10, 2026

Microscopy-based Assays for High-throughput Screening of Host Factors Involved in Brucella Infection of Hela Cells

Microscopy-based Assays for High-throughput Screening of Host Factors Involved in Brucella Infection of Hela Cells

Published on: August 5, 2016

Progress in Brucella vaccine development.

Xinghong Yang¹, Jerod A Skyberg, Ling Cao

¹Department of Immunology & Infectious Diseases, Montana State University, Bozeman, MT 59717-3610, USA.

Frontiers in Biology

|June 5, 2013

Summary

Brucellosis vaccines are crucial for both animal and human health. This review highlights promising new live and subunit vaccine candidates for brucellosis, offering improved safety and efficacy.

Keywords:

Brucella brucellosis livestock vaccines zoonosis

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Area of Science:

Veterinary Medicine
Infectious Diseases
Immunology

Background:

Brucella spp. are zoonotic pathogens causing significant animal and human disease, including abortions and flu-like symptoms.
Current antibiotic treatments for human brucellosis are lengthy and not always fully effective.
Existing live Brucella vaccines for livestock vary in performance based on host, dose, and administration route.

Purpose of the Study:

To review the current progress in brucellosis vaccine development.
To provide an overview of candidate vaccines for both animal and human applications.
To highlight novel vaccine strategies with enhanced safety and efficacy.

Main Methods:

Literature review of brucellosis vaccine research.
Analysis of existing licensed live Brucella vaccines for livestock.
Evaluation of newly engineered live and subunit vaccine candidates.

Main Results:

Newly engineered live vaccines offer high protection with low residual virulence and potential human applications.
Subunit vaccines demonstrate significant promise for livestock and human use due to enhanced safety and efficacy in animal models.
Vaccine performance is influenced by host species, dose, and immunization route.

Conclusions:

Advanced live and subunit vaccines are emerging as promising alternatives to current brucellosis control strategies.
These novel vaccines hold potential for broader applications in both veterinary and human medicine.
Continued research into Brucella vaccine development is essential for combating this zoonotic disease.